Changes in serum lipid concentrations during iron depletion and after iron supplementation.
Changes in serum lipid concentrations during iron depletion and after iron supplementation.
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发表时间：
2001-04
影响因子：
0.8
通讯作者：
Jong Weon Choi;Soon Ki Kim;S. Pai
中科院分区：
文献类型：
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作者：
Jong Weon Choi;Soon Ki Kim;S. Pai
为探讨缺铁和补铁对血脂的影响，对427名14-19岁女孩进行了血液学指标、铁标志物和血脂谱的测定。中度缺铁性贫血受试者之间的血清脂质浓度无显著差异（血Hb ≥ 14.0 g/dL（170 +/- 17 mg/dL）（p <14.0 g/dL），是重度贫血受试者的2倍。严重贫血女孩的血清总胆固醇和甘油三酯平均值（149 +/- 17 mg/dL和58 +/- 22 mg/dL）在补铁后显著升高（分别为164 +/- 17 mg/dL和98 +/- 26 mg/dL）（p < 0.01）。在重度贫血组中，血红蛋白浓度与血清总胆固醇（r = 0.49，p < 0.01）和甘油三酯（r = 0.51，p < 0.01）呈显著正相关。这些研究结果表明，严重缺铁性贫血的女孩参加了血清总胆固醇和甘油三酯的浓度降低，这些降低的血脂水平恢复正常后补充铁。
To investigate the effects of body iron depletion and iron supplementation on serum lipid concentrations, hematologic indices, iron markers, and serum lipid profiles were measured in 427 girls, age 14-19 yr. There were no significant differences in serum lipid concentrations between subjects with moderate iron deficiency anemia (blood Hb or = 14.0 g/dL (170 +/- 17 mg/dL) (p 14.0 g/dL was 2-fold higher than in the severely anemic subjects. Mean values of serum total cholesterol and triglyceride (149 +/- 17 mg/dL and 58 +/- 22 mg/dL) in girls with severe anemia were significantly elevated after iron supplementation (164 +/- 17 mg/dL and 98 +/- 26 mg/dL) (p < 0.01, respectively). In the severely anemic subjects, blood Hb concentration was correlated with serum total cholesterol (r = 0.49, p < 0.01) and triglyceride concentrations (r = 0.51, p < 0.01). These findings indicate that severe iron deficiency anemia in girls is attended by decreased concentrations of serum total cholesterol and triglyceride, and that these reduced serum lipid levels return to normal following iron supplementation.