Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion
Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion
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DOI：
10.1016/j.jaci.2009.03.001
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发表时间：
2009-04-01
影响因子：
14.2
通讯作者：
Sakaguchi, Shimon
中科院分区：
文献类型：
--
作者：
Miyara, Makoto;Wing, Kajsa;Sakaguchi, Shimon
叉头盒蛋白3阳性调节性T (Treg) 细胞对于维持自我耐受和免疫稳态是不可或缺的。它们还可以通过在体内激活和扩增抗原特异性 Treg 细胞来治疗免疫疾病，包括自身免疫性疾病和过敏。使用体外激活和扩增的 Treg 细胞进行细胞治疗可能是另一种治疗方式。基于我们对 Treg 细胞发育和功能的分子和细胞基础的理解的最新进展，讨论了这种基于 Treg 细胞的治疗策略的可行性。 （过敏临床免疫杂志 2009 年；123：749-55。）
Forkhead box protein 3-positive regulatory T (Treg) cells are indispensable for the maintenance of self-tolerance and immune homeostasis. They can also be exploited for the treatment of immunologic diseases, including autoimmune diseases and allergy, by way of activating and expanding antigen-specific Treg cells in vivo. Cell therapy with in vitro activated and expanded Treg cells can be another therapeutic modality. The feasibility of such Treg cell-based therapeutic strategies is discussed based on recent advances in our understanding of the molecular and cellular basis of Treg cell development and function. (J Allergy Clin Immunol 2009;123:749-55.)