Alzheimer's disease: diverse aspects of mitochondrial malfunctioning.
Alzheimer's disease: diverse aspects of mitochondrial malfunctioning.
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DOI：
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发表时间：
2010-06
影响因子：
1.4
通讯作者：
Renato X Santos;S. Correia;Xinglong Wang;George Perry;Mark A. Smith;P. Moreira;Xiongwei Zhu
中科院分区：
文献类型：
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作者：
Renato X Santos;S. Correia;Xinglong Wang;George Perry;Mark A. Smith;P. Moreira;Xiongwei Zhu
阿尔茨海默病是一种进行性神经退行性疾病，在较小部分病例中呈现散发性、年龄相关性、迟发性形式或家族性形式，具有早发性。而在家族性病例中，已经在编码与疾病发病机制相关的蛋白质的基因中鉴定出几种突变，对于散发形式，已经提出了几种原因，目前正在辩论中。线粒体功能障碍已成为讨论最多的假说之一，作为阿尔茨海默病发病机制的触发因素。线粒体在细胞中承担中心功能，包括ATP产生、钙稳态、活性氧产生和凋亡信号传导。虽然它们作为疾病原因的作用可能存在争议，但毫无疑问，线粒体功能障碍，线粒体动力学异常和线粒体自噬降解发生在疾病过程中，有助于其发病和进展。
Alzheimer's disease is a progressive neurodegenerative disorder, either assuming a sporadic, age-associated, late-onset form, or a familial form, with early onset, in a smaller fraction of the cases. Whereas in the familial cases several mutations have been identified in genes encoding proteins related with the pathogenesis of the disease, for the sporadic form several causes have been proposed and are currently under debate. Mitochondrial dysfunction has surfaced as one of the most discussed hypotheses acting as a trigger for the pathogenesis of Alzheimer's disease. Mitochondria assume central functions in the cell, including ATP production, calcium homeostasis, reactive oxygen species generation, and apoptotic signaling. Although their role as the cause of the disease may be controversial, there is no doubt that mitochondrial dysfunction, abnormal mitochondrial dynamics and degradation by mitophagy occur during the disease process, contributing to its onset and progression.