Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
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DOI：
10.1073/pnas.0909579106
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发表时间：
2009-12-15
影响因子：
11.1
通讯作者：
Keltner, Dacher
中科院分区：
文献类型：
--
作者：
Rodrigues, Sarina M.;Saslow, Laura R.;Keltner, Dacher
催产素是一种既充当激素又充当神经递质的肽，对整个身体和大脑的社交和情绪处理具有广泛的影响。在这项研究中，我们测试了催产素受体的多态性 (rs53576) 如何与催产素相关的两个关键社会过程相关：同理心和压力反应性。与 rs53576 (GG) 的 G 等位基因纯合个体相比，具有一个或两个 A 等位基因 (AG/AA) 拷贝的个体表现出较低的行为和性格同理心，通过“从眼睛里读心”测试和面向他人的同理心量表进行测量。此外，根据心率反应确定，AA/AG 个体比 GG 个体表现出更高的生理和性格应激反应性 在惊吓预期任务和情感反应量表中。我们的结果提供了证据，证明催产素受体自然发生的遗传变异如何与同理心和压力状况相关。
Oxytocin, a peptide that functions as both a hormone and neurotransmitter, has broad influences on social and emotional processing throughout the body and the brain. In this study, we tested how a polymorphism (rs53576) of the oxytocin receptor relates to two key social processes related to oxytocin: empathy and stress reactivity. Compared with individuals homozygous for the G allele of rs53576 (GG), individuals with one or two copies of the A allele (AG/AA) exhibited lower behavioral and dispositional empathy, as measured by the "Reading the Mind in the Eyes'' Test and an other-oriented empathy scale. Furthermore, AA/AG individuals displayed higher physiological and dispositional stress reactivity than GG individuals, as determined by heart rate response during a startle anticipation task and an affective reactivity scale. Our results provide evidence of how a naturally occurring genetic variation of the oxytocin receptor relates to both empathy and stress profiles.