Review of the Y chromosome and hypertension
Review of the Y chromosome and hypertension
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DOI：
10.1590/s0100-879x2000000600009
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发表时间：
2000-06-01
影响因子：
2.3
通讯作者：
Milsted, A
中科院分区：
文献类型：
--
作者：
Ely, D;Turner, M;Milsted, A
自发性高血压大鼠(SHR)的Y染色体有一个使血压升高20-25毫米汞柱的基因座，与SHR Y染色体效应相关的是青春期睾酮提前4周升高，并依赖雄激素受体来实现完整的血压效应。交感神经系统(SNS)活动增强的几个指标也与SHR Y染色体有关。阻断SNS外流可降低血压效应。Y染色体增加了对盐的敏感性，盐的食欲也增加了，这是SNS依赖的。相关系数r=0.57，P
The Y chromosome from spontaneously hypertensive rats (SHR) has a locus that raises blood pressure 20-25 mmHg, Associated with the SHR Y chromosome effect is a 4-week earlier pubertal rise of testosterone and dependence upon the androgen receptor for the full blood pressure effect. Several indices of enhanced sympathetic nervous system (SNS) activity are also associated with the SHR Y chromosome. Blockade of SNS outflow reduced the blood pressure effect. Salt sensitivity was increased by the Y chromosome as was salt appetite which was SNS dependent. A strong correlation (r = 0.57, P