Immunologic priming to capsular polysaccharide in infants immunized with Haemophilus influenzae type b polysaccharide-Neisseria meningitidis outer membrane protein conjugate vaccine.
Immunologic priming to capsular polysaccharide in infants immunized with Haemophilus influenzae type b polysaccharide-Neisseria meningitidis outer membrane protein conjugate vaccine.
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用 b 型流感嗜血杆菌多糖-脑膜炎奈瑟菌外膜蛋白结合疫苗免疫的婴儿对荚膜多糖的免疫启动。
DOI：
10.1016/s0022-3476(87)80336-0
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Granoff,DM
中科院分区：
文献类型：
--
作者：
Weinberg,GA;Einhorn,MS;Lenoir,AA;Granoff,PD;Granoff,DM
30名2至17个月大的儿童接种了与部分纯化的40,000道尔顿脑膜炎奈瑟菌外膜蛋白相关的流感嗜血杆菌b型多糖，10至14个月后再次接种了常规h疫苗。b型流感多糖疫苗。再免疫前抗b型抗体几何平均浓度为0.68 μg/mL， 1个月后血清抗b型抗体几何平均浓度上升至31 μg/mL。免疫后的平均水平与12例b型多糖疫苗免疫成人血清（51 μg/mL， P=0.3）无显著差异，比13例首次免疫b型多糖的对照儿童血清（2.7 μg/mL， P<0.001）高10倍。先接种结合疫苗再接种常规b型多糖疫苗的儿童IgG应答与免疫成人相似。此外，6至8个月后，这些儿童的血清抗体水平保持在较高水平。另外10名儿童在婴儿期接种结合疫苗，并在10至15个月后再次接种结合疫苗，显示出与婴儿期接种结合疫苗并加强常规多糖疫苗的组相似的抗体应答。因此接种h。b型流感多糖-外膜蛋白结合疫苗启动免疫系统对b型多糖或结合疫苗产生IgG记忆抗体反应。在补体介导的杀菌试验中，所有儿童的增强后血清显示出高滴度的功能活性。这些数据表明，大多数婴儿免受b型血友病的保护可以通过在2至4个月大时使用这种结合疫苗进行免疫，并在1年后使用结合或常规b型多糖疫苗进行再免疫来实现。
Thirty children vaccinated at 2 to 17 months of age withHaemophilus influenzaetype b polysaccharide linked to a partially purified 40,000 dalton outer membrane protein ofNeisseria meningitidiswere revaccinated 10 to 14 months later with conventionalH. influenzaetype b polysaccharide vaccine. The geometric mean anti-type b antibody concentration before reimmunization was 0.68 μg/mL, and rose to 31 μg/mL in sera obtained 1 month later. The mean level after immunization was not significantly different than that in sera from 12 adults immunized with type b polysaccharide vaccine (51 μg/mL, P=0.3), and was 10-foid higher than that of 13 control children immunized with type b polysaccharide for the first time (2.7 μg/mL, P<0.001). The IgG responses of the children first given conjugate vaccine and then conventional type b polysaccharide vaccine were of a similar magnitude as those in the immunized adults. Further, the children maintained high levels of serum antibody 6 to 8 months later. Ten other children vaccinated in infancy with conjugate vaccine, and again with conjugate vaccine 10 to 15 months later, showed similar antibody responses to those of the group given conjugate vaccine in infancy, and booster with conventional polysaccharide vaccine. Thus vaccination withH. influenzaetype b polysaccharide-outer membrane protein conjugate vaccine primes the immune system to an IgG memory antibody response to either type b polysaccharide or conjugate vaccine. Post-booster sera from all children tested showed high titers of functional activity in a complement-mediated bactericidal assay. These data suggest that protection of most infants from type bHaemophilusdisease may be achieved by a combination of immunization at 2 to 4 months of age with this conjugate vaccine, and reimmunization 1 year later with conjugate or conventional type b polysaccharide vaccine.
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影响因子：
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DOI：
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发表时间：
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期刊：
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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