A volumetric study of amygdala in cancer survivors with intrusive recollections
A volumetric study of amygdala in cancer survivors with intrusive recollections
复制标题
DOI：
10.1016/s0006-3223(02)01907-8
复制
发表时间：
2003-10-01
影响因子：
10.6
通讯作者：
Uchitomi, Y
中科院分区：
文献类型：
--
作者：
Matsuoka, Y;Yamawaki, S;Uchitomi, Y
背景资料：侵入性回忆是创伤后应激障碍（PTSD）的症状之一，经常发生在癌症幸存者身上，而不是PTSD的全部症状。PTSD的功能性神经影像学研究揭示了杏仁核对威胁相关刺激的高反应性，但没有体积研究发现杏仁核体积的改变。本研究的目的是评估杏仁核的结构改变的可能性，在癌症幸存者与侵入recognitions.Methods：磁共振成像体积分析的杏仁核进行了35例乳腺癌幸存者的历史，癌症相关的侵入性回忆和41例控制乳腺癌幸存者谁没有这样的历史。两组在年龄、身高、用手习惯、饮酒量和医学特征方面相似，但过去的重度抑郁症除外。结果：与对照组相比，有侵入性回忆史的受试者杏仁核的总体积明显较小。这一发现仍然是显着的控制后，年龄，身高，和重度depression disorder.Conclusions：这些结果表明，根据他们是否有癌症相关的侵入性回忆的癌症幸存者的杏仁核的体积的差异。(C)2003生物精神病学学会。
Background: Intrusive recollections, one of the re-experiencing symptoms of posttraumatic stress disorder (PTSD), frequently occur in cancer survivors rather than the full spectrum of the symptoms of PTSD. Functional neuroimaging studies of PTSD have revealed hyperresponsiveness to threat-related stimuli in the amygdala, but no volumetric studies have ever found alteration in the volume of the amygdala. The aim of the present study was to assess the possibility of structural alteration of the amygdala in cancer survivors with intrusive recollections.Methods: Magnetic resonance imaging volumetric analysis of the amygdala was performed in 35 breast cancer survivors with a history of cancer-related intrusive recollections and 41 control breast cancer survivors who had no such history. The groups were similar in age, height, handedness, alcohol consumption, and medical characteristics except for past major depressive disorder.Results: The total volume of the amygdala was significantly smaller in subjects with a history of intrusive recollections as compared with the control subjects. This finding continued to be significant after controlling for age, height, and major depressive disorder.Conclusions: These results suggest a difference in volume of the amygdala of cancer survivors according to whether they have had cancer-related intrusive recollections. (C) 2003 Society of Biological Psychiatry.