Novel bromopyrrole alkaloids from the sponge Agelas dispar
Novel bromopyrrole alkaloids from the sponge Agelas dispar
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DOI：
10.1021/np970323h
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发表时间：
1998-01-01
影响因子：
5.1
通讯作者：
Taglialatela-Scafati, O
中科院分区：
文献类型：
--
作者：
Cafieri, F;Fattorusso, E;Taglialatela-Scafati, O
对加勒比海洋海绵 Agelas dispar 的生物活性成分进行进一步研究，分离出新型溴吡咯生物碱 longamide B (1) 以及笼形酰胺 C (2) 和 D (3)，其结构已通过光谱方法确定。还报道了已知的角蛋白 (4) 以及蜕皮甾醇蜕皮甾酮 (5) 和阿朱加甾酮 C (6) 的分离。总结了分离的溴吡咯生物碱的抗菌活性。
Further investigation of the Caribbean marine sponge Agelas dispar for biologically active constituents has led to the isolation of the novel bromopyrrole alkaloids longamide B (1), and clathramides C (2) and D (3), whose structures have been determined by spectroscopic methods. Isolation of the known keramadine (4) and of the ecdysonic sterols ecdysterone (5) and ajugasterone C (6) is also reported. The antimicrobial activities of the isolated bromopyrrole alkaloids is summarized.