ProTISA: a comprehensive resource for translation initiation site annotation in prokaryotic genomes.
ProTISA: a comprehensive resource for translation initiation site annotation in prokaryotic genomes.
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ProTISA:原核基因组翻译起始位点注释的综合资源
DOI:
10.1093/nar/gkm799
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发表时间:
2008-01
影响因子:
14.9
通讯作者:
Zhu, Huaiqiu
中科院分区:
文献类型:
--
作者:
Hu, Gang-Qing;Zheng, Xiaobin;Yang, Yi-Fan;Ortet, Philippe;She, Zhen-Su;Zhu, Huaiqiu
Correct annotation of translation initiation site (TIS) is essential for both experiments and bioinformatics studies of prokaryotic translation initiation mechanism as well as understanding of gene regulation and gene structure. Here we describe a comprehensive database ProTISA, which collects TIS confirmed through a variety of available evidences for prokaryotic genomes, including Swiss-Prot experiments record, literature, conserved domain hits and sequence alignment between orthologous genes. Moreover, by combining the predictions from our recently developed TIS post-processor, ProTISA provides a refined annotation for the public database RefSeq. Furthermore, the database annotates the potential regulatory signals associated with translation initiation at the TIS upstream region. As of July 2007, ProTISA includes 440 microbial genomes with more than 390 000 confirmed TISs. The database is available at http://mech.ctb.pku.edu.cn/protisa
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影响因子:
3
作者:
Larsen TS;Krogh A
通讯作者:
Krogh A
影响因子:
5.8
作者:
Suzek, BE;Ermolaeva, MD;Salzberg, SL
通讯作者:
Salzberg, SL
影响因子:
4.4
作者:
Aivaliotis, Michalis;Gevaert, Kris;Oesterhelt, Dieter
通讯作者:
Oesterhelt, Dieter
影响因子:
3
作者:
Zhu H;Hu GQ;Yang YF;Wang J;She ZS
通讯作者:
She ZS
影响因子:
14.9
作者:
Besemer, J;Lomsadze, A;Borodovsky, M
通讯作者:
Borodovsky, M