Dose-response to exercise in women aged 45-75 yr (DREW): Design and rationale
Dose-response to exercise in women aged 45-75 yr (DREW): Design and rationale
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DOI：
10.1249/01.mss.0000113738.06267.e5
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发表时间：
2004-02-01
期刊：
影响因子：
--
通讯作者：
Blair, SN
中科院分区：
文献类型：
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作者：
Morss, GM;Jordan, AN;Blair, SN
介绍和目的：绝经后妇女缺乏体力活动导致与代谢综合征相关的动脉粥样硬化危险因素增加。虽然定期的身体活动对健康有积极的贡献，但随着年龄的增长，不活动的情况会逐渐增加。45-75岁女性运动剂量反应（DREW）研究旨在研究不同运动量对心血管疾病（CVD）风险中度增加的绝经后女性心肺适能和CVD风险因素的影响。方法：DREW将招募450名久坐不动的健康绝经后妇女，体重指数为25-40 kg。m（-2），静息收缩压（BP）为120-159 mm Hg，静息舒张压小于或等于99 mm Hg。在基线和6个月时完成的实验室和自我报告测量包括最大耗氧量（VO 2 max）、静息BP、人体测量、饮食习惯、体力活动史、药物使用、月经史、个人和家族病史以及空腹HDL胆固醇、LDL胆固醇、甘油三酯和葡萄糖。合格的参与者被随机分配到一个非运动组或三个运动组之一。参与者以相当于VO 2 max的50%的心率运动3至4 X wk（-1），消耗4、8或12 kcal（.）ka（-1.）wk（-1），取决于分组。本研究将允许量化运动训练和研究结果之间可能的剂量-反应关系（共识体力活动建议的50%、100%和150%）。结论：DREW可以为我们理解绝经后妇女体力活动的影响做出重要贡献，并帮助完善这一群体的公共卫生和临床建议。
Introduction and Purpose: Physical inactivity in postmenopausal women contributes to a rise in atherogenic risk factors associated with the metabolic syndrome. Although regular physical activity positively contributes to health, inactivity progressively increases with age. The Dose Response to Exercise in Women aged 45-75 yr (DREW) study is designed to investigate the effect of different amounts of exercise training on cardiorespiratory fitness and risk factors for cardiovascular disease (CVD) in postmenopausal women at moderately increased risk of CVD. Methods: DREW will recruit 450 sedentary, healthy, postmenopausal women with a body mass index of 25-40 kg(.)m(-2), resting systolic blood pressure (BP) of 120-159 mm Hg, and a resting diastolic BP of less than or equal to 99 mm Hg. Laboratory and self-report measures completed at baseline and 6 months include maximal oxygen consumption (VO2max), resting BP, anthropometry, dietary habits, physical activity history, medication use, menstrual history, personal and family medical history, and fasting HDL cholesterol, LDL cholesterol, triglycerides, and glucose. Eligible participants are randomly assigned to a nonexercise group or one of three exercise groups. Participants exercise 3 to 4 X wk(-1) at a heart rate equivalent to 50% of VO2max expending 4, 8, or 12 kcal(.)ka(-1.)wk(-1), depending on group assignment. This study will allow quantification of possible dose-response relations (50%, 100%, and 150% of the consensus physical activity recommendation) between exercise training and study outcomes. Conclusion: DREW can make important contributions to our understanding of the effects of physical activity in postmenopausal women and help refine public health and clinical recommendations for this group.