Mechanisms of combined action of different chemopreventive dietary compounds
Mechanisms of combined action of different chemopreventive dietary compounds
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DOI：
10.1007/s00394-008-2006-y
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发表时间：
2008-05-01
影响因子：
5
通讯作者：
Manson, Margaret M.
中科院分区：
文献类型：
--
作者：
de Kok, Theo M.;van Breda, Simone G.;Manson, Margaret M.
水果和蔬菜的消费通常与癌症发病率和心血管疾病的降低有关。多年来，许多生物活性化合物已被发现有助于这些有益的健康影响。最近，越来越多的证据表明，植物化学物质的特定组合在预防癌症方面可能比单独的化合物更有效。当任何一种单一药物失活时，已观察到组合效应。除了膳食微量营养素之间的相互作用之外，还观察到药物与植物化学物质的相互作用，这表明改进癌症治疗策略的可能性。我们对这种协同效应背后的分子机制的理解仍然有限，但似乎涉及互补作用模式的不同组合。在这篇综述中，我们讨论了可能参与癌症化学预防的分子机制，并总结了报告膳食化合物协同化学预防作用的研究中最重要的发现。
Consumption of fruits and vegetables has generally been associated with a decrease in cancer incidence and cardiovascular disease. Over the years, numerous bioactive compounds have been identified that contribute to these beneficial health effects. More recently, evidence is emerging that specific combinations of phytochemicals may be far more effective in protecting against cancer than isolated compounds. Combinatorial effects have been observed where any one of the single agents is inactive. Apart from interactions among dietary micronutrients, drug-phytochemical interactions have also been observed, indicating possibilities for improved cancer therapeutic strategies. Our understanding of the molecular mechanisms underlying such synergistic effects is still limited, but it appears that different combinations of complementary modes of actions are involved. In this review, we discuss the molecular mechanisms that are likely to be involved in cancer chemoprevention and summarize the most important findings of those studies that report synergistic chemopreventive effects of dietary compounds.