Models and mechanisms of experimental epilepsies
Models and mechanisms of experimental epilepsies
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DOI：
10.1111/j.0013-9580.2003.12004.x
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发表时间：
2003-01-01
期刊：
影响因子：
5.6
通讯作者：
Jefferys, JGR
中科院分区：
文献类型：
--
作者：
Jefferys, JGR
目的：回顾癫痫实验模型的价值，以帮助我们了解其潜在的基本神经机制。方法：本文涉及的方法包括各种急性和慢性实验性癫痫及其在体外、体内和计算机模拟中的研究。结果：癫痫放电是神经元网络的紧急特性，关键依赖于神经元的内在特性，以及相互连接的突触网络的结构和功能组织。快速振荡是这些网络的另一个新特性；虽然它们参与正常功能，但它们可以在至少某些类型的局灶性癫痫发作的启动中发挥关键作用。讨论：现在相对较好地理解了短暂的发作间歇性癫痫事件。慢性癫痫灶的机制，特别是局灶性癫痫发作的长时间超同步超兴奋性的机制相对较少，但在这方面也取得了进展，提供了更好的靶向治疗的前景。
Purpose: To review the value of experimental models of epilepsy to help us understand the underlying basic neuronal mechanisms.Methods: The methods addressed here include a variety of acute and chronic experimental epilepsies and their investigation in vitro, in vivo, and in computer simulations.Results: Epileptic discharges are emergent properties of neuronal networks, depending crucially on intrinsic neuronal properties, and on the structural and functional organisation of the synaptic networks that interconnect them. Fast oscillations are another emergent property of these networks; while they are involved in normal function, they can play a crucial role in the initiation of at least some kinds of focal seizure.Discussion: Brief "interictal" epileptic events are now relatively well understood. Rather less so are the mechanisms of chronic epileptic foci, and particularly of the prolonged hyper-synchronous hyperexcitability characteristic of focal seizures, but here too progress is being made, offering the prospect of better targeted treatments.