Tissue characterization identifies subjects with high risk of cardiovascular diseases
Tissue characterization identifies subjects with high risk of cardiovascular diseases
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DOI：
10.1016/j.diabres.2003.08.014
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发表时间：
2004-02-01
影响因子：
5.1
通讯作者：
Hori, M
中科院分区：
文献类型：
--
作者：
Katakami, N;Yamasaki, Y;Hori, M
目的：本研究旨在检查通过确定背向散射积分（IBS）对颈动脉壁进行组织表征是否可以识别近期有急性冠状动脉综合征（ACS）或动脉粥样硬化血栓性梗死（ATI）病史的受试者。研究设计和方法：应用超声测量132例2型糖尿病患者颈动脉内膜中层复合体最大厚度（Max-IMT）和IBS值（校正IBS），并与正常对照组比较。45岁，男性87例，女性45例），有或无心血管疾病。结果如下：近期合并ACS或ATI的糖尿病患者的校正IBS显著低于Max-IMT ≥ 1.1mm但无心血管疾病的患者，而Max-IMT显著高于Max-IMT ≥ 1.1mm但无心血管疾病的患者。近期ACS患者的最大IMT与校正IBS乘积（IMT-IBS乘积）显著低于慢性稳定型心绞痛患者。多因素Logistic回归分析显示，只有IMT-IBS产品与近期ACS（OR = 0.94，P < 0.05）和ATI（OR = 0.90，P < 0.005）病史相关。结论：有ACS或ATI病史的糖尿病患者颈动脉IBS值较低，IMT较高。颈动脉斑块的大小和组织特征都可以识别具有高心血管疾病风险的受试者。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Objective: This study was conducted to examine whether tissue characterization of the carotid artery wall by determining integrated backscatter (IBS) can identify subjects with a recent history of acute coronary syndrome (ACS) or atherothrombotic infarction (ATI). Research design and methods: The maximum thickness (Max-IMT) and IBS value (corrected-IBS) of the carotid artery intima-media complex were measured ultrasonographically for 132 type 2 diabetic subjects (62.9 +/- 8.5 (+/-S.D.) years old, 87 men and 45 women) with or without cardiovascular diseases. Results: The diabetic patients with recent ACS or ATI had a significantly lower corrected-IBS and higher Max-IMT than those with Max-IMT greater than or equal to 1.1 mm but without cardiovascular diseases. The product of Max-IMT and corrected-IBS (IMT-IBS product) of the patients with recent ACS was significantly lower than that of the patients with chronic stable angina. The multiple logistic model showed that only the IMT-IBS product was associated with a recent history of ACS (odds ratio 0.94, P < 0.05) and ATI (odds ratio 0.90, P < 0.005). Conclusions: Diabetic patients who had a recent history of ACS or ATI showed a lower IBS value and higher IMT for their carotid artery. Both the size and tissue characteristics of the carotid plaque may identify subjects with a high risk of cardiovascular disease. (C) 2003 Elsevier Ireland Ltd. All rights reserved.