THE BTB DOMAIN, FOUND PRIMARILY IN ZINC-FINGER PROTEINS, DEFINES AN EVOLUTIONARILY CONSERVED FAMILY THAT INCLUDES SEVERAL DEVELOPMENTALLY-REGULATED GENES IN DROSOPHILA
THE BTB DOMAIN, FOUND PRIMARILY IN ZINC-FINGER PROTEINS, DEFINES AN EVOLUTIONARILY CONSERVED FAMILY THAT INCLUDES SEVERAL DEVELOPMENTALLY-REGULATED GENES IN DROSOPHILA
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DOI：
10.1073/pnas.91.22.10717
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发表时间：
1994-10-25
影响因子：
11.1
通讯作者：
LASKI, FA
中科院分区：
文献类型：
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作者：
ZOLLMAN, S;GODT, D;LASKI, FA
果蝇bric a brac蛋白和由tramtrack和Broad-Complex编码的转录调节因子含有一个高度保守的约115个氨基酸的结构域，我们称之为BTB结构域。我们已经确定了6个额外的果蝇基因编码这个域。这些基因中有五个受到发育调控，其中一个似乎与bric a brac功能相关。BTB结构域定义了一个基因家族，在果蝇中估计有40个成员。该结构域主要发现于锌指蛋白的N末端，并且从果蝇到哺乳动物在进化上是保守的。
The Drosophila bric a brac protein and the transcriptional regulators encoded by tramtrack and Broad-Complex contain a highly conserved domain of approximate to 115 amino acids, which we have called the BTB domain. We have identified six additional Drosophila genes that encode this domain. Five of these genes are developmentally regulated, and one of them appears to be functionally related to bric a brac. The BTB domain defines a gene family with an estimated 40 members in Drosophila. This domain is found primarily at the N terminus of zinc finger proteins and is evolutionarily conserved from Drosophila to mammals.