Metal-Ion-Mediated Supramolecular Assembly of C-3-Peptides
Metal-Ion-Mediated Supramolecular Assembly of C-3-Peptides
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金属离子介导的 C-3-肽超分子组装
DOI：
10.1002/asia.201601721
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发表时间：
2017
影响因子：
4.1
通讯作者：
Zhang Afang
中科院分区：
文献类型：
--
作者：
Wang Jun;Shao Feng;Li Wen;Yan Jiatao;Liu Kun;Tao Pei;Masuda Toshio;Zhang Afang
研究了C3-苯-1，3，5-三甲酰胺类化合物在氢键和金属离子配位作用下的四肽Gly-Ala-Gly-Ala侧基超分子组装.选择Gly-Ala肽序列，因为它是蚕丝中最丰富的重复单元，并且已知通过有效的分子间氢键形成β-折叠。这些C3-肽在溶剂中形成长螺旋纤维，主要是由于强氢键。然而，在二价金属离子的存在下，这些螺旋纤维的手性通过金属配位增强，并可以转化为纳米球与过量的离子。不同的金属离子表现出不同的倾向，以介导的超分子手性，这甚至可以被逆转，根据协调的差异。
An investigation on a supramolecular assembly of C3‐molecules benzene‐1,3,5‐tricarboxamides carrying tetrapeptide Gly‐Ala‐Gly‐Ala pendants promoted by hydrogen bonding and metal ion coordination is described. A Gly‐Ala peptide sequence was selected as it is the most abundant repeating unit in silkworm silk, and known to form β‐sheets through efficient intermolecular hydrogen bonds. These C3‐peptides formed long helical fibers in solvents mainly owing to strong hydrogen bonding. However, in the presence of divalent metal ions, chirality of these helical fibers was enhanced through metal coordination and could be transformed into nanospheres with an excess amount of the ions. Different metal ions show different tendencies to mediate the supramolecular chirality, which can even be inverted according to coordination differences.