Hippocampus function predicts severity of post-traumatic stress disorder
Hippocampus function predicts severity of post-traumatic stress disorder
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DOI：
10.1089/cpb.2006.9.234
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发表时间：
2006-04-01
期刊：
影响因子：
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通讯作者：
Stevens, Mike
中科院分区：
文献类型：
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作者：
Astur, Robert S.;St Germain, Sarah A.;Stevens, Mike
创伤后应激障碍（PTSD）通常伴随着记忆问题和异常的大脑结构，特别是海马体。我们实施了一个跨物种，海马依赖的任务-虚拟Morris水任务-在功能磁共振成像（fMRI）过程中，评估PTSD患者和年龄匹配的对照组的海马功能。两组之间的任务表现相当。然而，当将该任务期间fMRI衍生的海马活动与PTSD严重程度相关联时，我们观察到-0.84相关性，表明海马活动减少的人表现出更严重的PTSD症状。这种相关性不能用任务表现、智商、创伤后持续时间和创伤后应激障碍时间的差异来解释。因此，PTSD的严重程度预测功能评估海马使用虚拟莫里斯水任务，这表明该任务可用于确定那些在创伤后发展PTSD的风险。
Post-traumatic stress disorder (PTSD) is often accompanied by memory problems and abnormal brain structure, particularly within the hippocampus. We implemented a cross-species, hippocampal-dependent task-the virtual Morris Water task-to assess hippocampal function in people with PTSD and age-matched controls during functional magnetic resonance imaging (fMRI). Performance on the task was equivalent between the groups. However, when correlating fMRI-derived hippocampal activity during this task with PTSD severity, we observe a -0.84 correlation, indicating that those with reduced hippocampal activity show more severe PTSD symptoms. This correlation is not explained by differences in task performance, IQ, duration since trauma, nor time with PTSD. Hence, PTSD severity is predicted by functionally assessing the hippocampus using the virtual Morris water task, suggesting that this task may be used to identify those at risk for developing PTSD following a trauma.