IL-19 and Other IL-20 Family Member Cytokines in Vascular Inflammatory Diseases.
IL-19 and Other IL-20 Family Member Cytokines in Vascular Inflammatory Diseases.
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DOI：
10.3389/fimmu.2018.00700
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发表时间：
2018
影响因子：
7.3
通讯作者：
Autieri MV
中科院分区：
文献类型：
--
作者：
Autieri MV
心血管疾病仍然是发达国家和发展中国家的主要医疗和社会经济负担，并将随着老龄化和日益久坐的社会而增加。许多血管疾病和动脉粥样硬化性血管疾病，特别是，本质上是炎症性疾病，涉及多种细胞类型。这些细胞之间的通信是由细胞因子及其受体的复杂网络启动和维持的。白细胞介素（IL）-20家族成员IL-19、IL-20、IL-22和IL-24启动、维持和驱动血管疾病的进展。它们在血管疾病中很重要，因为它们促进了常驻血管细胞与免疫细胞之间的双向串扰。这些细胞因子基于共享的共同受体亚基和信号传导途径被分组为同一家族。这种沟通是多种多样的，并可能导致恶化，衰减，甚至修复脉管系统。我们将简要回顾一下IL-20、IL-22和IL-24在心血管生物学中的已知情况。由于IL-19是这个家族中研究最多的成员，在其在血管病理生理过程中的作用，本次审查的主要重点将集中在表达和动脉粥样硬化保护作用的IL-19在血管炎症性疾病。
Cardiovascular disease remains a major medical and socioeconomic burden in developed and developing countries and will increase with an aging and increasingly sedentary society. Many vascular diseases and atherosclerotic vascular disease, in particular, are essentially inflammatory disorders, involving multiple cell types. Communication between these cells is initiated and sustained by a complex network of cytokines and their receptors. The interleukin (IL)-20 family members, IL-19, IL-20, IL-22, and IL-24, initiate, sustain, and drive the progression of vascular disease. They are important in vascular disease as they facilitate a bidirectional cross-talk between resident vascular cells with immune cells. These cytokines are grouped into the same family based on shared common receptor subunits and signaling pathways. This communication is varied and can result in exacerbation, attenuation, and even repair of the vasculature. We will briefly review what is known about IL-20, IL-22, and IL-24 in cardiovascular biology. Because IL-19 is the most studied member of this family in terms of its role in vascular pathophysiological processes, the major emphasis of this review will focus on the expression and atheroprotective roles of IL-19 in vascular inflammatory disease.
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影响因子：
5
作者：
Hsieh, MY;Chen, WY;Chang, MS
通讯作者：
Chang, MS
影响因子：
5.5
作者：
Gabunia, Khatuna;Jain, Surbhi;Autieri, Michael V.
通讯作者：
Autieri, Michael V.
DOI：
10.1161/atvbaha.113.301521
发表时间：
2013-10
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Ellison S;Gabunia K;Kelemen SE;England RN;Scalia R;Richards JM;Orr AW;Traylor JG Jr;Rogers T;Cornwell W;Berglund LM;Goncalves I;Gomez MF;Autieri MV
通讯作者：
Autieri MV
影响因子：
3.1
作者：
Lee, Ki-Mo;Kang, Haeng-A.;Kang, Hyung-Sik
通讯作者：
Kang, Hyung-Sik
影响因子：
5
作者：
Gallagher, G;Dickensheets, H;Kotenko, SV
通讯作者：
Kotenko, SV