H3N2 Canine Influenza Virus Infection in a Dog
H3N2 Canine Influenza Virus Infection in a Dog
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DOI：
10.1177/0300985816681411
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发表时间：
2017-05-01
影响因子：
2.4
通讯作者：
Toohey-Kurth, K.
中科院分区：
文献类型：
--
作者：
Watson, C. E.;Bell, C.;Toohey-Kurth, K.
2015年，大芝加哥地区的狗身上出现了H3N2犬流感。在此期间，一只 10 岁的德国牧羊犬向转诊兽医提出嗜睡和咳嗽的症状，很快就死亡了。本报告描述了宏观和微观病变以及为鉴定新型北美 H3N2 犬流感病毒株而进行的分子检测。喉、咽和气管被纤维蛋白坏死膜覆盖。双肺尾肺叶多灶性胸膜下坏死，伴有出血、充血和肺水肿。从肺中分离出假中间葡萄球菌。通过实时聚合酶链反应从鼻道、口咽、喉、气管和颅肺叶中鉴定出食蟹猴支原体。从这只狗身上分离到的流感病毒的神经氨酸酶基因序列与芝加哥地区流行的病毒株有98%的同源性。
In 2015, H3N2 canine influenza emerged in dogs in the greater Chicago area. During this time, a 10-year-old German Shepherd dog presented to the referring veterinarian with lethargy and coughing that quickly progressed to death. This report describes the macroscopic and microscopic lesions and the molecular testing performed to identify the novel North American H3N2 strain of canine influenza. The larynx, pharynx, and trachea were covered by a fibrinonecrotic membrane. Bilaterally, the lungs had multifocal subpleural necrosis of the caudal lung lobes with hemorrhage, congestion, and pulmonary edema. Staphylococcus pseudointermedius was isolated from the lung. Mycoplasma cynos was identified by real-time polymerase chain reaction from nasal passages, oropharynx, larynx, trachea, and cranial lung lobes. The neuraminidase gene sequence from the influenza virus isolated obtained from this dog had 98% homology to the strain circulating in the Chicago area.