Aberrant Topological Properties of Brain Functional Network in Children with Obstructive Sleep Apnea Derived from Resting-State fMRI
Aberrant Topological Properties of Brain Functional Network in Children with Obstructive Sleep Apnea Derived from Resting-State fMRI
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DOI：
10.1007/s10548-022-00920-1
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发表时间：
2022-10-18
期刊：
影响因子：
2.7
通讯作者：
Ni, Xin
中科院分区：
文献类型：
--
作者：
Ji, Tingting;Ren, Xuemin;Ni, Xin
探讨阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）儿童与正常儿童脑功能网络拓扑结构的差异及其与OSA儿童认知功能评分的关系。24名OSA儿童（6.5 ± 2.8岁，15名男性）和26名健康对照（8.0 ± 2.9岁，11名男性）接受了静息态fMRI（rs-fMRI），在此基础上构建了脑功能网络。我们比较了OSA儿童和健康对照组之间的网络的全局和区域拓扑特性。偏相关分析进行拓扑性质和认知得分之间的OSA儿童。OSA组儿童的全面智商（FIQ）和言语智商（VIQ）低于对照组。此外，结的程度集中性下降，在双侧前扣带回和副扣带回，但增加在右侧额中回，左侧梭状回，左侧缘上回。右侧中央前回、双侧扣带回前部和扣带回旁的节点效率降低，左侧梭状回的节点效率升高。在右侧额上级回、左侧梭状回和左侧缘上回的背外侧部分，节点介数中心性增加。此外，在左侧缘上回的节点的程度中心与FIQ呈正相关。相比之下，两组之间的全局拓扑性质没有差异。OSA的结果可能损害了OSA儿童脑功能网络的局部拓扑特性，这可能是导致OSA儿童认知功能下降的潜在神经机制。
To examine the difference in the topological properties of brain functional network between the children with obstructive sleep apnea (OSA) and healthy controls, and to explore the relationships between these properties and cognitive scores of OSA children. Twenty-four OSA children (6.5 +/- 2.8 years, 15 males) and 26 healthy controls (8.0 +/- 2.9 years, 11 males) underwent resting-state fMRI (rs-fMRI), based on which brain functional networks were constructed. We compared the global and regional topological properties of the network between OSA children and healthy controls. Partial correlation analysis was performed between topological properties and cognitive scores across OSA children. When comparing the OSA children with the healthy controls, lower full-scale intelligent quotient (FIQ) and verbal intelligent quotient (VIQ) were observed. Additionally, nodal degree centrality decreased in the bilateral anterior cingulate and paracingulate gyrus, but increased in the right middle frontal gyrus, the left fusiform gyrus, and the left supramarginal gyrus. Nodal efficiency decreased in the right precentral gyrus, and the bilateral anterior cingulate and paracingulate gyrus, but increased in the left fusiform gyrus. Nodal betweenness centrality increased in the dorsolateral part of the right superior frontal gyrus, the left fusiform gyrus, and the left supramarginal gyrus. Further, the nodal degree centrality in the left supramarginal gyrus was positively correlated with FIQ. In contrast, none of global topological properties showed difference between those two groups. The outcomes of OSA may impaired the regional topological properties of the brain functional network of OSA children, which may be potential neural mechanism underlying the cognitive declines of these patients.