A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus.
A possible role for glycoprotein gpV in the pathogenesis of varicella-zoster virus.
复制标题
糖蛋白 gpV 在水痘带状疱疹病毒发病机制中的可能作用。
DOI：
10.1007/978-1-4684-5853-4_9
复制
发表时间：
1990
影响因子：
--
通讯作者：
Ruyechan,WT
中科院分区：
文献类型：
--
作者：
Kinchington,PR;Ling,P;Pensiero,M;Gershon,A;Hay,J;Ruyechan,WT
水痘-带状疱疹病毒（Varicella-zoster virus，VZV）是人类已知的六种疱疹病毒之一。它是水痘（水痘）的病原体，作为原发感染和带状疱疹（带状疱疹）的结果，从潜伏状态重新激活。一些考虑清楚地表明，我们必须扩大对这种病毒自然史的了解。首先，美国一般人群年龄的增加可能导致带状疱疹复发病例的增加，并伴随发病率的增加。其次，水痘和带状疱疹都可以导致免疫功能低下的全身性和潜在的危及生命的感染。第三，VZV减毒活疫苗已在日本广泛使用，并正在美国完成临床试验（1）。
Varicella-zoster virus (VZV) is one of the six known human herpesviruses. It is the causative agent of chicken pox (varicella) as the result of primary infection and shingles (zoster) upon reactivation from the latent state. A number of considerations make it clear that our knowledge of the natural history of this virus must be expanded. First, the increasing age of the general population in the United States is likely to lead to an increase in cases of recrudescent zoster with attendant morbidity. Second, both varicella and zoster can lead to systemic and potentially life-threatening infections in the immunocompromised. Third, a live attenuated VZV vaccine has been used extensively in Japan and is completing clinical trials in the United States (1).