Folate and the methylenetetrahydrofolate reductase 677C→T mutation correlate with cognitive performance
Folate and the methylenetetrahydrofolate reductase 677C→T mutation correlate with cognitive performance
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DOI：
10.1016/j.neurobiolaging.2005.01.003
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发表时间：
2006-02-01
影响因子：
4.2
通讯作者：
Verhoef, P
中科院分区：
文献类型：
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作者：
Durga, J;van Boxtel, MPJ;Verhoef, P
低叶酸状态与认知能力下降有关。我们研究了叶酸状态和5，10-亚甲基四氢叶酸还原酶（MTHFR）677 C-> T多态性与一系列神经心理学测试的相关性。此外，我们研究了叶酸与认知能力的关系是否是由血浆同型半胱氨酸或血管疾病风险介导的。我们使用了818名年龄在50-70岁之间的人的横断面数据。低浓度的红细胞叶酸而不是血清叶酸与复杂的速度和记忆任务的表现不佳，独立于教育水平和血管疾病的传统危险因素。这些相关性不受同型半胱氨酸浓度或颈动脉内膜中层厚度的影响。具有MTHFR 677 TT基因型的受试者倾向于在认知任务上比CC/CT受试者表现得更好，尽管这仅在感觉运动速度上是显著的（MTHFR 677 TT纯合子和CC纯合子之间的7个评分的差异为-0.15，95%Cl：-0.30至0.00）。低浓度的红细胞叶酸与认知能力下降有关，可能是通过一种不依赖同型半胱氨酸的机制，如DNA失真和线粒体衰变。(C)2005年爱思唯尔公司All rights reserved.
Low folate status has been associated with cognitive decline. We investigated the association of folate Status and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C --> T polymorphism with performance on a battery of neuropsychological tests. Furthermore, we investigated whether the association of folate with cognitive performance was mediated by plasma homocysteine or risk of vascular disease. We used cross-sectional data from 818 individuals aged 50-70 years old. Low concentrations of erythrocyte folate but not serum folate were associated with poor performance on complex speed and memory tasks, independent of educational level and conventional risk factors of vascular disease. These associations were not mediated by homocysteine concentrations or carotid intima-media thickness. Subjects with the MTHFR 677TT genotype tended to perform better on cognitive tasks than CC/CT subjects, although this was significant for sensorimotor speed only (differences in 7 scores between MTHFR 677TT homozygotes and CC homozygotes -0.15, 95% Cl: -0.30 to 0.00). Low concentrations of erythrocyte folate are associated with decreased cognitive performance, possibly through a homocysteine-independent mechanism Such as DNA infidelity and mitochondrial decay. (C) 2005 Elsevier Inc. All rights reserved.