A striking diurnal variation in plasma testosterone concentrations in infantile male rhesus monkeys (Macaca mulatta).
A striking diurnal variation in plasma testosterone concentrations in infantile male rhesus monkeys (Macaca mulatta).
复制标题
幼年雄性恒河猴（Macaca mulatta）血浆睾酮浓度的显着昼夜变化。
DOI：
10.1159/000123409
复制
发表时间：
1982
影响因子：
4.1
通讯作者：
Plant,TM
中科院分区：
文献类型：
--
作者：
Plant,TM
通过放射免疫测定法测定了幼雄性恒河猴在09.00和21.00 h时采集的血液样品中的睾酮（T），幼雄性恒河猴与其母亲在受控光周期（06.00-18.00 h光照）下饲养在单独的笼子中。在出生后的前6周内，夜间血浆达特浓度（3.9 ± 1.7-7.0 ± 0.8 ng/ml;平均值± SEM）约为早晨血浆Tat浓度（0.8 ± 0.1-2.0 ± 0.6 ng/ml）的3- 6倍。夜间循环T升高，然后逐渐下降，直到约30周龄时，血浆T浓度在早晨和晚上达到最低点，变得难以区分。1周龄双侧睾丸切除术完全消除了夜间血浆T浓度的升高。幼年恒河猴睾丸T分泌的这种显著的昼夜变化似乎与完全成年的动物相似。这些研究结果提供了进一步的证据支持这样的观点，即在这个物种中，下丘脑-垂体装置，管辖睾丸功能是完全成熟的新生儿发育阶段。
Testosterone (T) was measured by radioimmunoassay in blood samples taken at 09.00 and 21.00 h in infantile male rhesus monkeys maintained in individual cages with their mothers under a controlled photoperiod (lights on 06.00-18.00 h). During the first 6 weeks of life, concentrations of plasma Tat night (3.9 ± 1.7–7.0 ± 0.8 ng/ml; mean ± SEM) were approximately 3- to 6-fold greater than those in the morning (0.8 ± 0.1–2.0 ± 0.6 ng/ml). The nocturnal elevation in circulating T then declined progressively until approximately 30 weeks of age when plasma T concentrations in the morning and evening reached their nadir and became indistinguishable. Bilateral orchidectomy at 1 week of age completely abolished the nighttime elevation in plasma T concentration. This striking diurnal variation in testicular T secretion in the infantile rhesus monkey appears to be similar to that in the fully adult animal. These findings provide further evidence in support of the view that, in this species, the hypothalamic-pituitary apparatus that governs testicular function is fully mature by the neonatal stage of development.