Roles of RecA homologues Rad51 and Dmc1 during meiotic recombination
Roles of RecA homologues Rad51 and Dmc1 during meiotic recombination
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DOI：
10.1159/000080598
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发表时间：
2004-01-01
影响因子：
1.7
通讯作者：
Shinohara, M
中科院分区：
文献类型：
--
作者：
Shinohara, A;Shinohara, M
RecA蛋白参与重组过程中的同源性搜索和链交换过程。真核生物中的有丝分裂细胞表达一种RecA，Rad51，其对于双链断裂（DSB）的修复是必需的。此外，减数分裂细胞诱导第二个RecA，Dmc 1。Rad51和Dmc 1都是同源染色体之间产生交叉所必需的，这确保了减数分裂I时染色体的分离。在减数分裂重组过程中，这两个RecA如何合作在很大程度上是未知的。本文就Rad51和Dmc 1在减数分裂过程中的作用作一综述。版权所有（C）2004 S. Karger AG，巴塞尔。
RecA protein is involved in homology search and strand exchange processes during recombination. Mitotic cells in eukaryotes express one RecA, Rad51, which is essential for the repair of double-strand breaks (DSBs). Additionally, meiotic cells induce the second RecA, Dmc1. Both Rad51 and Dmc1 are necessary to generate a crossover between homologous chromosomes, which ensures the segregation of the chromosomes at meiotic division I. It is largely unknown how the two RecAs cooperate during meiotic recombination. In this review, recent advances on our knowledge about the roles of Rad51 and Dmc1 during meiosis are summarized and discussed. Copyright (C) 2004 S. Karger AG, Basel.