Determination of parameters for successful spray coating of silicon microneedle arrays
Determination of parameters for successful spray coating of silicon microneedle arrays
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DOI：
10.1016/j.ijpharm.2011.05.064
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发表时间：
2011-08-30
影响因子：
5.8
通讯作者：
Crean, Abina M.
中科院分区：
文献类型：
--
作者：
McGrath, Marie G.;Vrdoljak, Anto;Crean, Abina M.
包膜微针贴片已被证明具有有效、微创的药物和疫苗递送潜力。为了促进具有成本效益的、工业规模的涂覆微针贴片的生产，利用传统制药工艺的连续涂覆方法是一个有吸引力的前景。本研究评估了传统薄膜涂层工艺喷涂硅微针贴片的潜力，并通过采用分数因子设计对平面硅贴片进行涂层，确定了影响涂层聚结和重量的关键工艺参数。分析的工艺参数包括涂层材料浓度、液体输入速率、喷涂时间、雾化空气压力、枪与表面距离和气帽设置。研究了两种薄膜涂层材料；羟丙基甲基纤维素（HPMC）和羧甲基纤维素（CMC）。当确定合适的喷涂参数时，HPMC可以在硅表面形成膜层。CMC薄膜需要加入表面活性剂（1%，w/w吐温80），以促进喷射液滴在硅表面的聚并。通过实验设计确定的喷涂参数，成功地喷涂了280 μ m的硅微针阵列，产生了完整的薄膜涂层，该涂层遵循微针阵列的轮廓而不遮挡微针的形状。本研究展示了一种利用传统薄膜涂层工艺将生物相容性聚合物涂覆在微针阵列上的新方法。这是首次研究微针阵列涂层的厚度和粗糙度。该研究还强调了在微米尺寸的基材上涂膜时确定合适的工艺参数的重要性。分数因子设计识别这些关键参数的能力也得到了证明。在本研究中应用的聚合物涂层有可能用于皮内药物和疫苗递送的药物负载。(C) 2011 Elsevier B.V.版权所有
Coated microneedle patches have demonstrated potential for effective, minimally invasive, drug and vaccine delivery. To facilitate cost-effective, industrial-scale production of coated microneedle patches, a continuous coating method which utilises conventional pharmaceutical processes is an attractive prospect. Here, the potential of spray-coating silicon microneedle patches using a conventional film-coating process was evaluated and the key process parameters which impact on coating coalescence and weight were identified by employing a fractional factorial design to coat flat silicon patches. Processing parameters analysed included concentration of coating material, liquid input rate, duration of spraying, atomisation air pressure, gun-to-surface distance and air cap setting. Two film-coating materials were investigated; hydroxypropylmethylcellulose (HPMC) and carboxymethylcellulose (CMC). HPMC readily formed a film-coat on silicon when suitable spray coating parameter settings were determined. CMC films required the inclusion of a surfactant (1%, w/w Tween 80) to facilitate coalescence of the sprayed droplets on the silicon surface. Spray coating parameters identified by experimental design, successfully coated 280 mu m silicon microneedle arrays, producing an intact film-coat, which follows the contours of the microneedle array without occlusion of the microneedle shape. This study demonstrates a novel method of coating microneedle arrays with biocompatible polymers using a conventional film-coating process. It is the first study to indicate the thickness and roughness of coatings applied to microneedle arrays. The study also highlights the importance of identifying suitable processing parameters when film coating substrates of micron dimensions. The ability of a fractional factorial design to identify these critical parameters is also demonstrated. The polymer coatings applied in this study can potentially be drug loaded for intradermal drug and vaccine delivery. (C) 2011 Elsevier B.V. All rights reserved.