Young Alzheimer patients show distinct regional changes of oscillatory brain dynamics
Young Alzheimer patients show distinct regional changes of oscillatory brain dynamics
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DOI：
10.1016/j.neurobiolaging.2011.10.013
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发表时间：
2012-05-01
影响因子：
4.2
通讯作者：
van der Flier, Wiesje M.
中科院分区：
文献类型：
--
作者：
de Waal, Hanneke;Stam, Cornelis J.;van der Flier, Wiesje M.
本研究的目的是使用定量脑电描记术（EEG）检查阿尔茨海默病（AD）中不同发病年龄的振荡脑动力学差异。我们检查了320名可能的AD患者和246名对照者的静息状态脑电图，两者都被归类为年轻（65岁）组。计算了4个不同频段的相对功率。研究了年龄对全球和区域相对权力的影响。在全球范围内，年轻AD患者比老年AD患者表现出更低的α功率和更高的δ功率。区域分析表明，这些差异在顶枕区最为明显。年轻的AD患者有较低的β功率和较高的θ功率比老年患者在所有，但颞区。在对照组中，在任何频带中的全局相对功率均无年龄效应。年轻AD患者比老年AD患者存在更严重的自发振荡活动减慢，这在后脑区最明显。这一发现支持了早发性AD具有独特的内表型的假设。(C)2012 Elsevier Inc. All rights reserved.
The objective of this study was to examine the differences in oscillatory brain dynamics in Alzheimer's disease (AD) according to age at onset using quantitative electroencephalography (EEG). We examined resting state electroencephalograms of 320 probable AD patients and 246 controls, both categorized into a young (65 years) group. Relative power in 4 different frequency bands was calculated. The effect of age on global and regional relative power was examined. Globally, young AD patients showed lower alpha- and higher delta-power than old AD patients. Regional analysis showed that these differences were most pronounced in the parieto-occipital region. Young AD patients had lower beta- and higher theta-power than old patients in all but the temporal regions. In controls, there was no age effect on global relative power in any frequency band. Young AD patients present with more severe slowing of spontaneous oscillatory activity than old AD patients, which is most pronounced in the posterior brain areas. This finding supports the hypothesis that early onset AD presents with a distinct endophenotype. (C) 2012 Elsevier Inc. All rights reserved.