Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans.

Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans.
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DOI:
10.3390/vaccines9010061
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发表时间:
2021-01-18
期刊:
影响因子:
7.8
通讯作者:
Loré K
Loré K
中科院分区:
医学3区
文献类型:
--
作者:
Cagigi A;Loré K

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在这篇简明的综述中,我们总结了mRNA疫苗接种背后的概念。我们讨论了mRNA疫苗在不同动物模型和人类中产生的先天和适应性免疫反应。我们给出了mRNA疫苗已显示可诱导有效反应的病毒感染的例子,并更详细地讨论了最近在人体中进行的SARS-CoV-2 mRNA疫苗试验。
In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.
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