Trends in the incidence of deep vein thrombosis and pulmonary embolism -: A 25-year population-based study
Trends in the incidence of deep vein thrombosis and pulmonary embolism -: A 25-year population-based study
复制标题
DOI：
10.1001/archinte.158.6.585
复制
发表时间：
1998-03-23
影响因子：
--
通讯作者：
Melton, LJ
中科院分区：
文献类型：
--
作者：
Silverstein, MD;Heit, JA;Melton, LJ
背景：静脉血栓栓塞症的发病率尚未得到很好的描述，也没有关于静脉血栓栓塞症发病率的长期趋势的研究。目的：估计深静脉血栓形成和肺栓塞的发病率，并描述发病率的趋势。方法：我们对居住在明尼苏达州奥姆斯特县的2218名患者的完整医疗记录进行了回顾，这些患者在1966-1990年的25年间发生过深静脉血栓或肺栓塞。结果：总体平均年龄和性别调整后的静脉血栓年发病率为117/10万(深静脉血栓形成，48/10万，000)。男性的年龄调整发病率高于女性(分别为130/10万和110/10万)。静脉血栓栓塞症的发生率随着年龄的增长而显著增加，其中肺血栓栓塞症是增加的主要原因。在研究的最后15年中，无论是男性还是所有年龄层，肺血栓的发生率都降低了约45%，而深静脉血栓的发生率在所有年龄段的男性中保持不变，在55岁以下的女性中下降，在60岁以上的女性中上升。结论：静脉血栓栓塞症是一个主要的国家健康问题，尤其是在老年人中。虽然肺栓塞的发生率随着时间的推移而下降，但男性深静脉血栓的发生率保持不变，而老年女性的发生率正在上升。这些发现强调了需要更准确地识别静脉血栓栓塞症的风险患者，以及安全有效的预防措施。
Background: The incidence of venous thromboembolism has not been well described, and there are no studies of long-term trends in the incidence of venous thromboembolism.Objectives: To estimate the incidence of deep vein thrombosis and pulmonary embolism and to describe trends in incidence.Methods: We performed a retrospective review of the complete medical records from a population-based inception cohort of 2218 patients who resided within Olmsted Country, Minnesota, and had an incident deep vein thrombosis or pulmonary embolism during the 25-year period from 1966 through 1990.Results: The overall average age-and sex-adjusted annual incidence of venous thromboembolism was 117 per 100 000 (deep vein thrombosis, 48 per 100 000, pulmonary embolism, 69 per 100 000), with higher age-adjusted rates among males than females (130 vs 110 per 100 000, respectively). The incidence of venous thromboembolism rose markedly with increasing age for both sexes, with pulmonary embolism accounting for most of the increase. The incidence of pulmonary embolism was approximately 45% lower during the last 15 years of the study for both sexes and all age strata, while the incidence of deep vein thrombosis remained constant for males across all age strata, decreased for females younger than 55 years, and increased for women older than 60 years.Conclusions: Venous thromboembolism is a major national health problem, especially among the elderly. While the incidence of pulmonary embolism has decreased over time, the incidence of deep vein thrombosis remains unchanged for men and is increasing for older women. These findings emphasize the need for more accurate identification of patients at risk for venous thromboembolism, as well as a safe and effective prophylaxis.