Rapid induction of antigen-specific CD4(+) T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination.
Rapid induction of antigen-specific CD4(+) T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination.
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抗原特异性CD 4（+）T细胞的快速诱导与对SARS-CoV-2 mRNA疫苗的协调体液和细胞免疫相关
DOI：
10.1016/j.immuni.2021.08.001
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发表时间：
2021-09-14
期刊：
影响因子：
32.4
通讯作者：
Wherry EJ
中科院分区：
文献类型：
--
作者：
Painter MM;Mathew D;Goel RR;Apostolidis SA;Pattekar A;Kuthuru O;Baxter AE;Herati RS;Oldridge DA;Gouma S;Hicks P;Dysinger S;Lundgreen KA;Kuri-Cervantes L;Adamski S;Hicks A;Korte S;Giles JR;Weirick ME;McAllister CM;Dougherty J;Long S;D'Andrea K;Hamilton JT;Betts MR;Bates P;Hensley SE;Grifoni A;Weiskopf D;Sette A;Greenplate AR;Wherry EJ
SARS-CoV-2mRNA疫苗已显示出显著的临床效果，但T细胞启动的性质和动力学仍存在疑问。我们对健康的SARS-CoV-2初治者和恢复者在mRNA启动和加强接种前后进行了纵向抗原特异性T细胞分析。第一剂疫苗接种后，幼稚受试者迅速产生抗原特异性的CD4+T细胞反应，而CD8+T细胞反应逐渐发展，且大小不一。第一剂疫苗诱导的Th1和Tfh细胞反应分别与增强后CD8+T细胞和中和抗体相关。综合分析显示，在SARS-CoV-2幼稚和康复个体中，协调免疫反应具有不同的轨迹。最后，虽然加强免疫可以改善SARS-CoV-2初学者的T细胞反应，但第二次接种对SARS-CoV-2恢复的人几乎没有影响。这些发现突显了快速启动的CD4+T细胞在协调SARS-CoV-2幼稚个体对第二剂疫苗的反应中的作用。SARS-CoV-2mRNA疫苗已经显示出显著的效果，但T细胞对疫苗的反应还没有得到很好的研究。在纵向队列中，Painter等人。显示，mRNA疫苗激活了SARS-CoV-2特异性T细胞，这可能有助于持久免疫。这一发现突显了T细胞在之前未感染SARS-CoV-2的个人的两剂疫苗方案中的核心作用。
SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific T cell analyses on healthy SARS-CoV-2-naive and recovered individuals prior to and following mRNA prime and boost vaccination. Vaccination induced rapid antigen-specific CD4+ T cell responses in naive subjects after the first dose, whereas CD8+ T cell responses developed gradually and were variable in magnitude. Vaccine-induced Th1 and Tfh cell responses following the first dose correlated with post-boost CD8+ T cells and neutralizing antibodies, respectively. Integrated analysis revealed coordinated immune responses with distinct trajectories in SARS-CoV-2-naive and recovered individuals. Last, whereas booster vaccination improved T cell responses in SARS-CoV-2-naive subjects, the second dose had little effect in SARS-CoV-2-recovered individuals. These findings highlight the role of rapidly primed CD4+ T cells in coordinating responses to the second vaccine dose in SARS-CoV-2-naive individuals. SARS-CoV-2 mRNA vaccines have demonstrated remarkable efficacy, but T cell responses to vaccination have not been well studied. In a longitudinal cohort, Painter et al. show that mRNA vaccines activate SARS-CoV-2-specific T cells that could contribute to durable immunity. The findings highlight the central role of T cells in the two-dose vaccine regimen for individuals not previously infected with SARS-CoV-2.
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DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
24.8
作者：
Goel RR;Apostolidis SA;Painter MM;Mathew D;Pattekar A;Kuthuru O;Gouma S;Hicks P;Meng W;Rosenfeld AM;Dysinger S;Lundgreen KA;Kuri-Cervantes L;Adamski S;Hicks A;Korte S;Oldridge DA;Baxter AE;Giles JR;Weirick ME;McAllister CM;Dougherty J;Long S;D'Andrea K;Hamilton JT;Betts MR;Luning Prak ET;Bates P;Hensley SE;Greenplate AR;Wherry EJ
通讯作者：
Wherry EJ
SARS-COV-2 mRNA疫苗促进与中和抗体产生相关的有效抗原特异性生发中心反应。
影响因子：
32.4
作者：
Lederer K;Castaño D;Gómez Atria D;Oguin TH 3rd;Wang S;Manzoni TB;Muramatsu H;Hogan MJ;Amanat F;Cherubin P;Lundgreen KA;Tam YK;Fan SHY;Eisenlohr LC;Maillard I;Weissman D;Bates P;Krammer F;Sempowski GD;Pardi N;Locci M
通讯作者：
Locci M
DOI：
10.1001/jama.2020.19759
发表时间：
2020-10-20
期刊：
JAMA
影响因子：
--
作者：
Cutler DM;Summers LH
通讯作者：
Summers LH
DOI：
10.1084/jem.186.9.1407
发表时间：
1997-11-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hamann D;Baars PA;Rep MH;Hooibrink B;Kerkhof-Garde SR;Klein MR;van Lier RA
通讯作者：
van Lier RA