Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry
Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry
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DOI：
10.2116/analsci.26.1099
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发表时间：
2010-10-01
影响因子：
1.6
通讯作者：
Seno, Hiroshi
中科院分区：
文献类型：
--
作者：
Ogawa, Tadashi;Hattori, Hideki;Seno, Hiroshi
建立了一种快速、灵敏的血浆中布南色林的超高效液相色谱-串联质谱分析方法。用C（18）柱分析布南色林。方法的回收率、重现性和线性范围为0.01 ~ 10.0 ng/mL。该方法的检出限低至1 pg/mL，可用于法医学、临床毒理学和药代动力学研究
A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented After pretreatment of a plasma sample by solid-phase extraction. blonanserin was analyzed by the system with a C(18) column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 001 - 10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies