The emergence of salivary cortisol circadian rhythm and its relationship to sleep activity in preterm infants
The emergence of salivary cortisol circadian rhythm and its relationship to sleep activity in preterm infants
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DOI：
10.1111/j.1365-2265.2000.tb00561.x
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发表时间：
2000-04-01
影响因子：
3.2
通讯作者：
Moreira, AC
中科院分区：
文献类型：
--
作者：
Antonini, SRR;Jorge, SM;Moreira, AC
目的 足月儿的皮质醇昼夜节律在出生后 8 至 12 周之间建立。然而，关于早产对这种节律的影响的信息有限。我们评估了早产儿唾液皮质醇昼夜节律的出现及其与每日睡眠节律开始的关系。设计和患者对九名早产儿（胎龄31-34周）进行了一项纵向研究。在产后第2周、第4周、第8周、第12周、第16周、第20周和第24周的早晨和晚上采集唾液样本，并由母亲记录婴儿的睡眠时间。测量通过RIA测定25μl唾液样本中的皮质醇。两种基于变异系数的技术被用来表征皮质醇的昼夜节律模式。 结果 5 名婴儿 (55%) 在出生后第 2 周和第 8 周建立并维持了皮质醇节律。其余四名婴儿的出生年龄分别为 12 周和 16 周。这种节律在产后 8 至 12 周期间在整个群体中出现。从出生后第八周开始检测睡眠的昼夜节律。结论我们的数据表明，在这组早产儿中，下丘脑-垂体-肾上腺轴的昼夜节律成熟发生在与足月婴儿报道的相同的出生后年龄，并且这种节律的出现与睡眠节律的开始之间存在平行性。
OBJECTIVE The circadian rhythm of cortisol is established at between 8 and 12 postnatal weeks in term infants. However, there is limited information about the effect of prematurity on this rhythm. We evaluated the emergence of the salivary cortisol circadian rhythm in premature infants and its relationship to the onset of sleep daily rhythm.DESIGN AND PATIENTS A longitudinal study of a group of nine premature infants (gestational age 31-34 weeks) was performed. Salivary samples were obtained in the morning and at night at 2, 4, 8, 12, 16, 20 and 24 postnatal weeks and the babies' sleeping periods were recorded by their mothers.MEASUREMENTS Cortisol was determined by RIA in 25-mu l salivary samples. Two techniques based on assay coefficients of variation were used to characterize the circadian pattern of cortisol.RESULTS Five infants (55%) established and maintained their cortisol rhythm at 2 and 8 postnatal weeks. In the remaining four infants the age of appearance was 12 and 16 weeks. This rhythm emerged in the group as a whole between 8 and 12 postnatal weeks. The circadian rhythm of sleep was detected starting from the eighth postnatal week.CONCLUSIONS Our data suggest that in this group of premature infants the circadian maturation of the hypothalamic-pituitary-adrenal axis occurred at the same postnatal age as reported for term infants and that there was a parallelism between the appearance of such rhythm and the onset of sleep rhythm.