Analysis of the Dynamic Behavior of the Inner Hair Cell Stereocilia by the Finite Element Method
Analysis of the Dynamic Behavior of the Inner Hair Cell Stereocilia by the Finite Element Method
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DOI：
10.1299/jsmec.49.828
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发表时间：
2006-09
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影响因子：
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通讯作者：
T. Matsui;C. Nakajima;Yui Yamamoto;M. Andoh;Koji Iida;M. Murakoshi;S. Kumano;H. Wada
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文献类型：
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作者：
T. Matsui;C. Nakajima;Yui Yamamoto;M. Andoh;Koji Iida;M. Murakoshi;S. Kumano;H. Wada
内毛细胞（IHC）静纤毛的运动，导致连接到机械门控离子通道的尖端链接中的张力，介导听觉转导过程。然而，由于静纤毛的微小尺寸和复杂结构，很难直接观察到静纤毛的运动。在这项研究中，调查这样的运动，高，中，短的IHC静纤毛，包括尖端和侧链之间的静纤毛，有限元方法模型的构建。通过施加一个解析估计的流体力所造成的60分贝SPL在500赫兹的刺激模型，静纤毛的动态行为进行了分析。结果表明，静纤毛的运动是同相的，最大张力分别出现在连接高、中静纤毛的端部连接处和连接中、短静纤毛的端部连接处，最大张力分别为2.5fN和2.1fN。相比之下，在去除侧链的条件下，前者的最大张力增加到11.6fN，而后者仅增加到2.3fN。因此，建议横向连接保护位于较高静纤毛处的MET通道免受大的刺激，并使位于相同IHC中的通道受到类似大小的力。
The motion of the inner hair cell (IHC) stereocilia, which results in tension in the tip links connected to mechanically gated ion channels, mediates the auditory transduction process. However, it is difficult to directly observe the motion of the stereocilia because of their minute dimensions and complex structure. In this study, to investigate such motion, a finite element method model of the tall, middle and short IHC stereocilia, including the tip and lateral links extending between the stereocilia, was constructed. By applying an analytically estimated fluid force caused by a stimulus of 60dB SPL at 500Hz to the model, the dynamic behavior of the stereocilia was analyzed. Numerical results showed that the stereocilia moved in phase and that the maximum tensions of 2.5fN and 2.1fN occurred in the tip link connecting the tall and middle stereocilia and in the tip link connecting the middle and short stereocilia, respectively. By contrast, under the condition in which the lateral links were removed, maximum tension in the former increased to 11.6fN, while that in the latter only increased to 2.3fN. It was therefore suggested that the lateral links protect the MET channels located at taller stereocilia against large stimuli and subject the channels located in the same IHC to forces of similar size.