Functional topography of primary emotion processing in the human cerebellum
Functional topography of primary emotion processing in the human cerebellum
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DOI：
10.1016/j.neuroimage.2012.03.044
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发表时间：
2012-07-16
期刊：
影响因子：
5.7
通讯作者：
Mattingley, Jason B.
中科院分区：
文献类型：
--
作者：
Baumann, Oliver;Mattingley, Jason B.
小脑在运动的控制和协调中起着重要作用。然而，现在很清楚的是，小脑也参与了各种感知和认知功能的神经过程，包括情绪反应的调节。当代情绪的神经生物学模型断言，一小部分离散的情绪通过不同的皮质和皮质下区域进行调节。鉴于连接小脑和这些区域的神经通路的连接特异性，我们假设小脑的不同亚区可能有助于不同初级情绪的处理。我们使用功能磁共振成像(FMRI)来识别30名健康人类志愿者小脑内的神经活动模式，因为他们对引发五种主要情绪的图像进行了分类：快乐、愤怒、厌恶、恐惧和悲伤。为了支持我们的假设，所有五种情绪都在小脑后叶引起了空间上不同的活动模式。我们还检测到特定情绪类别的小脑激活之间的重叠，这意味着共享神经网络的存在。通过提供小脑情绪处理的详细功能图谱，我们的研究为小脑病理对人类情感功能的不同影响提供了重要线索。(C)2012 Elsevier Inc.保留所有权利。
The cerebellum has an important role in the control and coordination of movement. It is now clear, however, that the cerebellum is also involved in neural processes underlying a wide variety of perceptual and cognitive functions, including the regulation of emotional responses. Contemporary neurobiological models of emotion assert that a small set of discrete emotions are mediated through distinct cortical and subcortical areas. Given the connectional specificity of neural pathways that link the cerebellum with these areas, we hypothesized that distinct sub-regions of the cerebellum might subserve the processing of different primary emotions. We used functional magnetic resonance imaging (fMRI) to identify neural activity patterns within the cerebellum in 30 healthy human volunteers as they categorized images that elicited each of the five primary emotions: happiness, anger, disgust, fear and sadness. In support of our hypothesis, all five emotions evoked spatially distinct patterns of activity in the posterior lobe of the cerebellum. We also detected overlaps between cerebellar activations for particular emotion categories, implying the existence of shared neural networks. By providing a detailed map of the functional topography of emotion processing in the cerebellum, our study provides important clues to the diverse effects of cerebellar pathology on human affective function. (C) 2012 Elsevier Inc. All rights reserved.