Left ventricular assist device effects on metabolic substrates in the failing heart.
Left ventricular assist device effects on metabolic substrates in the failing heart.
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DOI：
10.1371/journal.pone.0060292
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lowes BD
中科院分区：
文献类型：
--
作者：
Weitzel LB;Ambardekar AV;Brieke A;Cleveland JC;Serkova NJ;Wischmeyer PE;Lowes BD
心力衰竭患者营养摄入不足，代谢改变，导致整体能量耗尽状态。左心室辅助装置（LVAD）支持是终末期心力衰竭患者常见且成功的干预措施。LVAD支持导致心输出量、功能状态、神经激素活性和转录谱的改变，但LVAD对心肌代谢的影响尚不清楚。本研究旨在测量非衰竭心脏、衰竭心脏和LVAD支持后心脏的心脏代谢物。研究人群包括8个非缺血性衰竭（LVAD植入时）和8个LVAD后心脏，以及从科罗拉多大学组织库获得的8个非衰竭心脏。利用NMR光谱来评价心肌能量底物的差异。使用配对和非配对t检验确定适当组之间的差异。葡萄糖和乳酸值均从非衰竭心脏下降到衰竭心脏，并在（配对）LVAD后心脏中再次显著升高。谷氨酰胺、丙氨酸和芳香族氨基酸从非衰竭心脏到衰竭心脏降低，并且在LVAD后没有显著变化。总肌酸和琥珀酸从非衰竭心脏下降到衰竭心脏，并且在LVAD后没有显著变化。与葡萄糖代谢相关的代谢产物在衰竭的心脏中减少，但在LVAD后恢复其值。这与氨基酸水平不同，氨基酸水平在心力衰竭中下降，但在LVAD后没有恢复。肌酸和柠檬酸循环中间体琥珀酸遵循与氨基酸水平相似的模式。
Heart failure patients have inadequate nutritional intake and alterations in metabolism contributing to an overall energy depleted state. Left ventricular assist device (LVAD) support is a common and successful intervention in patients with end-stage heart failure. LVAD support leads to alterations in cardiac output, functional status, neurohormonal activity and transcriptional profiles but the effects of LVADs on myocardial metabolism are unknown. This study set out to measure cardiac metabolites in non-failing hearts, failing hearts, and hearts post-LVAD support. The study population consisted of 8 non-ischemic failing (at LVAD implant) and 8 post-LVAD hearts, plus 8 non-failing hearts obtained from the tissue bank at the University of Colorado. NMR spectroscopy was utilized to evaluate differences in myocardial energy substrates. Paired and non-paired t-tests were used to determine differences between the appropriate groups. Glucose and lactate values both decreased from non-failing to failing hearts and increased again significantly in the (paired) post-LVAD hearts. Glutamine, alanine, and aromatic amino acids decreased from non-failing to failing hearts and did not change significantly post-LVAD. Total creatine and succinate decreased from non-failing to failing hearts and did not change significantly post-LVAD. Measured metabolites related to glucose metabolism are diminished in failing hearts, but recovered their values post-LVAD. This differed from the amino acid levels, which decreased in heart failure but did not recover following LVAD. Creatine and the citric acid cycle intermediate succinate followed a similar pattern as the amino acid levels.
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影响因子：
37.8
作者：
Cheng S;Rhee EP;Larson MG;Lewis GD;McCabe EL;Shen D;Palma MJ;Roberts LD;Dejam A;Souza AL;Deik AA;Magnusson M;Fox CS;O'Donnell CJ;Vasan RS;Melander O;Clish CB;Gerszten RE;Wang TJ
通讯作者：
Wang TJ
影响因子：
158.5
作者：
Rose, EA;Gelijns, AC;Meier, P
通讯作者：
Meier, P
影响因子：
3.4
作者：
Wischmeyer, PE;Jayakar, D;Serkova, N
通讯作者：
Serkova, N
DOI：
10.1016/0735-1097(95)00555-2
发表时间：
1996-03-15
影响因子：
24
作者：
Nakatani, S;McCarthy, PM;Thomas, JD
通讯作者：
Thomas, JD
影响因子：
19.6
作者：
Serkova, N;Fuller, TF;Niemann, CU
通讯作者：
Niemann, CU