YAP Activation in Promoting Negative Durotaxis and Acral Melanoma Progression.
YAP Activation in Promoting Negative Durotaxis and Acral Melanoma Progression.
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DOI：
10.3390/cells11223543
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发表时间：
2022-11-09
期刊：
影响因子：
6
通讯作者：
Wu, Congying
中科院分区：
文献类型：
--
作者：
Huang, Yuxing;Su, Jing;Liu, Jiayong;Yi, Xin;Zhou, Fang;Zhang, Jiaran;Wang, Jiaxiang;Meng, Xuan;Si, Lu;Wu, Congying
定向细胞迁移到一个更软的环境被称为负性硬旋转。在肿瘤进展中，阴性硬脊膜扩张的机制和病理相关性仍需深入研究。在这里，我们报告说，雅普促进黑色素瘤的阴性硬脊膜扩张。我们发现RhoA-肌球蛋白II通路可能是雅普增强黑色素瘤细胞的负性硬旋转的基础。肢端黑色素瘤是非白种人中最常见的黑色素瘤亚型，并且倾向于在承受压力的区域发展。我们报告肢端黑色素瘤患者表现出雅普扩增和增加的雅普活性。我们检测到肢端黑色素瘤微环境中从肿瘤到周围区域的刚度梯度逐渐减小。我们进一步确定，这种刚度梯度可以促进黑色素瘤细胞的负性硬旋转。我们的研究推进了对肢端黑色素瘤中机械力和雅普的理解，我们提出了阴性硬旋转作为黑色素瘤播散的新机制。
Directed cell migration towards a softer environment is called negative durotaxis. The mechanism and pathological relevance of negative durotaxis in tumor progression still requires in-depth investigation. Here, we report that YAP promotes the negative durotaxis of melanoma. We uncovered that the RhoA-myosin II pathway may underlie the YAP enhanced negative durotaxis of melanoma cells. Acral melanoma is the most common subtype of melanoma in non-Caucasians and tends to develop in a stress-bearing area. We report that acral melanoma patients exhibit YAP amplification and increased YAP activity. We detected a decreasing stiffness gradient from the tumor to the surrounding area in the acral melanoma microenvironment. We further identified that this stiffness gradient could facilitate the negative durotaxis of melanoma cells. Our study advanced the understanding of mechanical force and YAP in acral melanoma and we proposed negative durotaxis as a new mechanism for melanoma dissemination.
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影响因子：
21.3
作者：
Miroshnikova YA;Mouw JK;Barnes JM;Pickup MW;Lakins JN;Kim Y;Lobo K;Persson AI;Reis GF;McKnight TR;Holland EC;Phillips JJ;Weaver VM
通讯作者：
Weaver VM
影响因子：
64.8
作者：
Barriga EH;Franze K;Charras G;Mayor R
通讯作者：
Mayor R
影响因子：
12.7
作者：
Dube, Umber;Ibanez, Laura;Cruchaga, Carlos
通讯作者：
Cruchaga, Carlos
影响因子：
64.8
作者：
Coste, Bertrand;Xiao, Bailong;Santos, Jose S.;Syeda, Ruhma;Grandl, Joerg;Spencer, Kathryn S.;Kim, Sung Eun;Schmidt, Manuela;Mathur, Jayanti;Dubin, Adrienne E.;Montal, Mauricio;Patapoutian, Ardem
通讯作者：
Patapoutian, Ardem
影响因子：
10.9
作者：
Jung, Ho Joo;Kweon, Sun-Seog;Yun, Sook Jung
通讯作者：
Yun, Sook Jung