EFFECT OF CALCIUM-IONS ON BINOMIAL STATISTIC PARAMETERS WHICH CONTROL ACETYLCHOLINE-RELEASE AT SYNAPSES IN STRIATED-MUSCLE
EFFECT OF CALCIUM-IONS ON BINOMIAL STATISTIC PARAMETERS WHICH CONTROL ACETYLCHOLINE-RELEASE AT SYNAPSES IN STRIATED-MUSCLE
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DOI：
10.1113/jphysiol.1975.sp010939
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发表时间：
1975-01-01
影响因子：
5.5
通讯作者：
HALL, R
中科院分区：
文献类型：
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作者：
BENNETT, MR;FLORIN, T;HALL, R
本文研究了改变[Ca]O和[Mg]O对控制乙酰胆碱释放引起的突触电位平均量子含量（m）的二项式统计参数p和n的影响。2.当[Ca]O在0-1至1 - 0 mM范围内变化时，p以[Ca]O的一次方增加，而n以[Ca]O的三次方增加。3.增加[Mg]O会降低p和n，但高[Mg]O条件下[Ca]O的变化不会显著改变p和[Ca]O之间或n和[Ca]O之间的幂关系。4.在短期训练过程中，m的易化增加是由于n的增加，而在破伤风过程中，m的强直后增加是由于p的增加。这些结果被认为是钙离子在易化和强直后增强中的作用。
A study has been made of the effects of changing [Ca]O and [Mg]O on the binomial statistic parameters p and n which control the average quantal content (m) of the synaptic potential due to acetylcholine release. 2. When [Ca]O was varied in the range 0–1 to 1‐0 mM, p increased as the first power of [Ca]O whereas n increased as the third power of [Ca]O. 3. Increasing [Mg]O depressed both p and n, however variations of [Ca]O in the presence of high [Mg]O did not significantly change the power relationship between either p and [Ca]O or between n and [Ca]O. 4. The facilitated increase in m during a short train was due to an increase in n, whereas the post‐tetanic increase in m during a tetanus was due to an increase in p. These results are considered in terms of the role of Ca ions in facilitation and post‐tetanic potentiation.