A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics.
A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics.
复制标题
仔细观察Schlemm的运河细胞生理学：对仿生物的影响。
DOI：
10.3390/jfb6030963
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发表时间：
2015-09-21
影响因子：
4.8
通讯作者：
Sharfstein ST
中科院分区：
文献类型：
--
作者：
Dautriche CN;Tian Y;Xie Y;Sharfstein ST
在眼部疾病中，青光眼是渐进性视力丧失的第二大原因，预计到2020年将影响全球8000万人。青光眼的主要原因似乎是对传统流出道的损害。传统的流出组织，小梁网和Schlemm管的复合物，调节和维持对眼内压的稳态反应。在青光眼中，水状液过滤到施累姆氏管中受阻，导致眼内压升高和随后的视神经损伤，伴随进行性视力丧失。施累姆氏管包括独特的内皮。在培养和操纵施累姆氏管细胞的最新进展已经阐明了其生理学的几个方面，包括超微结构，细胞特异性标记物表达和生物力学特性。本文综述了这些进展，并讨论了工程的3D，仿生，体外模型的施莱姆氏管内皮进一步推进青光眼研究，包括药物测试和基因治疗筛选的影响。
Among ocular pathologies, glaucoma is the second leading cause of progressive vision loss, expected to affect 80 million people worldwide by 2020. A primary cause of glaucoma appears to be damage to the conventional outflow tract. Conventional outflow tissues, a composite of the trabecular meshwork and the Schlemm’s canal, regulate and maintain homeostatic responses to intraocular pressure. In glaucoma, filtration of aqueous humor into the Schlemm’s canal is hindered, leading to an increase in intraocular pressure and subsequent damage to the optic nerve, with progressive vision loss. The Schlemm’s canal encompasses a unique endothelium. Recent advances in culturing and manipulating Schlemm’s canal cells have elucidated several aspects of their physiology, including ultrastructure, cell-specific marker expression, and biomechanical properties. This review highlights these advances and discusses implications for engineering a 3D, biomimetic, in vitro model of the Schlemm’s canal endothelium to further advance glaucoma research, including drug testing and gene therapy screening.