CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS
CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS
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某些外部分泌物共有的免疫系统特征
DOI：
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发表时间：
1965
影响因子：
15.3
通讯作者：
R. A. Prendergast
中科院分区：
文献类型：
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作者：
T. Tomasi;E. Tan;A. Solomon;R. A. Prendergast
唾液和初乳中的γ - 1a主要以高聚物的形式存在，其主要成分的沉降系数为11S。这些液体中的11S γ1A在免疫学上与正常和骨髓瘤血清中的聚合物不同，而且在没有尿素的情况下，它们的沉降系数不受二硫键还原的影响。然而，像其他γ-球蛋白一样，11S γ1A分子由由二硫键连接的多个多肽链组成。荧光和放射自显影研究显示唾液腺中γ - 1a的局部合成，尽管唾液腺中来自局部产生的γ - 1a总量的比例尚不确定。没有证据表明静脉注射i131标记的7S γ1A从血清转运到唾液。免疫特异性已证实在唾液和初乳γ - 1a。这部分具有免疫特异性的γ - 1a是在腺体局部合成γ - 1a的过程中被纳入，还是在运输过程中被上皮细胞加入，目前尚不清楚。抗体活性（等血凝素）已在唾液和初乳中证实，并已被证明是γ 1a型。在这两种流体中，活性主要与11S和18S尺寸的γ - 1a聚合物有关。似乎有一种免疫系统以某些外部分泌物为特征。它的特性包括局部产生一种独特类型的抗体，这将它与负责产生循环抗体的“系统”系统区分开来。这个系统可能在人体对抗过敏原和微生物的防御机制中发挥重要作用。
The γ1A present in saliva and colostrum exists largely in the form of higher polymers, the major component of which has a sedimentation coefficient of 11S. The 11S γ1A in these fluids differs from the polymers found in normal and myeloma sera both immunologically and by the fact that their sedimentation coefficients are unaffected by disulfide bond reduction in the absence of urea. However, like other γ-globulins the 11S γ1A molecules consist of multiple polypeptide chains linked by disulfide bonds. Local synthesis of γ1A in the salivary gland has been shown by fluorescent and autoradiographic studies, although the fraction of the total salivary γ1A which is derived from local production is uncertain. No evidence of transport of intravenously administered I131-labeled 7S γ1A from serum to saliva was obtained. Immunological specificity has been demonstrated in the salivary and colostral γ1A. Whether that portion of the γ1A which is immunologically specific is a piece incorporated during the local synthesis of γ1A in the gland or is added by the epithelial cell in the process of transport remains to be determined. Antibody activity (isohemagglutinins) have been demonstrated in saliva and colostrum and have been shown to be of the γ1A-type. In both of these fluids activity is associated primarily with γ1A-polymers of 11S and 18S sizes. There appears to be an immunological system which is characteristic of certain external secretions. Its properties including the local production of a distinctive type of antibody separate it from the "systemic" system responsible for the production of circulating antibody. This system may play a significant role in the body's defense mechanisms against allergens and microorganisms.