Windows of Lead Exposure Sensitivity, Attained Height, and Body Mass Index at 48 Months
Windows of Lead Exposure Sensitivity, Attained Height, and Body Mass Index at 48 Months
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DOI：
10.1016/j.jpeds.2011.12.022
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发表时间：
2012-06-01
影响因子：
5.1
通讯作者：
Tellez-Rojo, Martha M.
中科院分区：
文献类型：
--
作者：
Afeiche, Myriam;Peterson, Karen E.;Tellez-Rojo, Martha M.
目的 研究敏感时期产前、婴儿期和幼儿期铅暴露与身高和体重指数 (BMI) 的纵向关联。 研究设计 1994 年至 2005 年间在墨西哥城招募了总共 773 名参与者。铅暴露历史类别是针对产前时期（母亲髌骨铅浓度）以及婴儿期和儿童期（分别是出生至 24 个月和 30-48 个月的儿童平均血铅浓度）构建的。使用线性回归模型研究铅暴露史与 48 个月时身高和 BMI 的关系。 结果 婴儿期血铅水平超过中值的儿童 (-0.84 cm；95% CI，-1.42 至 -0.25) 48 个月时的平均身高显着低于血铅水平低于中值的儿童。产前铅暴露与 48 个月时的身高无关。 BMI 的结果通常与身高的趋势相同。 结论 我们的研究结果表明，生命早期接触铅对 48 个月时身高的影响，其中婴儿期的接触窗口最敏感。 (J Pediatr 2012；160:1044-9)。
Objective To examine longitudinal associations of prenatal, infancy, and early childhood lead exposure during sensitive periods with height and body mass index (BMI).Study design A total of 773 participants were recruited between 1994 and 2005 in Mexico City. Lead exposure history categories were constructed for the prenatal period (maternal patellar lead concentration) and for infancy and childhood (mean child blood lead concentration at birth to 24 months and 30-48 months, respectively). Linear regression models were used to study lead exposure history with height and BMI at 48 months.Results Mean height at age 48 months was significantly lower in children with a blood lead level exceeding the median during infancy (-0.84 cm; 95% CI, -1.42 to -0.25) than in children with a level below the median. Prenatal lead exposure was not associated with height at 48 months. Results for attained BMI generally trended in the same direction as for height.Conclusion Our findings suggest an effect of lead exposure early in life on height attainment at 48 months, with the exposure window of greatest sensitivity in infancy. (J Pediatr 2012; 160:1044-9).