Preventive effects of black soybean polyphenols on non-alcoholic fatty liver disease in three different mouse models
Preventive effects of black soybean polyphenols on non-alcoholic fatty liver disease in three different mouse models
复制标题
黑豆多酚对三种不同小鼠模型非酒精性脂肪肝的预防作用
DOI：
10.1039/d1fo03541j
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发表时间：
2022
期刊：
影响因子：
6.1
通讯作者：
Ashida Hitoshi
中科院分区：
文献类型：
--
作者：
Yamamoto Mio;Yoshioka Yasukiyo;Kitakaze Tomoya;Yamashita Yoko;Ashida Hitoshi
非酒精性脂肪性肝病(NAFLD)及其晚期非酒精性脂肪性肝炎(NASH)是世界范围内的主要健康问题。某些食物成分，如多酚，有望对非酒精性脂肪肝和非酒精性脂肪肝具有预防作用。本研究采用三种NAFLD/NASH动物模型，研究了黑大豆多酚的预防作用。在胆碱缺乏和L氨基酸定义的高脂饮食诱导的NASH模型中，黑大豆多酚的摄入减少了氧化应激，但不能减轻肝损伤和减少α-平滑肌肌动蛋白(α-SMA)的表达。在含有蔗糖和果糖的西式饮食中，黑大豆多酚抑制了肝脏脂肪堆积、氧化应激、血浆转氨酶活性、炎性细胞因子的表达和α-SMA的表达，并伴随着脂代谢的调节。在西方饮食和四氯化碳模型的组合中，黑大豆多酚还抑制肝脏脂质堆积、氧化应激、血浆转氨酶活性和α-SMA的表达。综上所述，黑豆具有很强的抗氧化活性，是一种有吸引力的预防非酒精性脂肪肝和非酒精性脂肪肝的食物。
Non-alcoholic fatty liver disease (NAFLD) and its advanced stage, non-alcoholic steatohepatitis (NASH), are a major health issue throughout the world. Certain food components such as polyphenols are expected to possess preventive effects on NAFLD and NASH. In this study, the preventive effects of black soybean polyphenols were examined by using three NAFLD/NASH animal models. In a choline-deficient and L-amino acid-defined high-fat diet-induced NASH model, the intake of black soybean polyphenols decreased oxidative stress, but failed in attenuating liver injury and decreasing the expression of alpha-smooth muscle actin (α-SMA). In a Western diet with sucrose and fructose containing sweetened water-induced NAFLD model, black soybean polyphenols suppressed hepatic lipid accumulation, oxidative stress, aminotransferase activities in the plasma, inflammatory cytokine expression, and α-SMA expression accompanied by modulation of lipid metabolism. In a combination of Western diet and carbon tetrachloride model, black soybean polyphenols also suppressed hepatic lipid accumulation, oxidative stress, aminotransferase activities in the plasma, and α-SMA expression. In conclusion, black soybean is an attractive food for the prevention of NAFLD and NASH due to its strong antioxidant activity.