Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.
Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.
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DOI：
10.1016/j.molcel.2016.12.020
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发表时间：
2017-02-02
期刊：
影响因子：
16
通讯作者：
Moldovan GL
中科院分区：
文献类型：
--
作者：
Choe KN;Moldovan GL
增殖细胞核抗原（PCNA）是真核生物基因组复制的核心。由于其独特的甜甜圈形分子结构，PCNA最初被研究为刺激DNA聚合酶的作用。然而，我们现在知道PCNA不仅仅是促进进行性DNA合成。由于所涉及事件的复杂性，细胞DNA复制对基因组完整性构成了重大威胁。无论复制叉面临什么样的困境，PCNA都能协调处理它所需的事件。通过其许多蛋白质相互作用和各种翻译后修饰，PCNA对无数细胞功能产生深远的影响。
Proliferating Cell Nuclear Antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.