Revealing the world of RNA interference
Revealing the world of RNA interference
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DOI：
10.1038/nature02872
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发表时间：
2004-09-16
期刊：
影响因子：
64.8
通讯作者：
Conte, D
中科院分区：
文献类型：
--
作者：
Mello, CC;Conte, D
最近发现的RNA干扰和相关的RNA沉默途径已经彻底改变了我们对基因调控的理解。RNA干扰已被用作控制许多实验生物体中特定基因表达的研究工具，并有可能作为减少问题基因表达的治疗策略。RNA干扰的核心是一种显着的RNA加工机制，现在已知它是许多不同生物现象的基础。
The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce the expression of problem genes. At the heart of RNA interference lies a remarkable RNA processing mechanism that is now known to underlie many distinct biological phenomena.