Accelerated atherosclerosis in autoimmune rheumatic diseases
Accelerated atherosclerosis in autoimmune rheumatic diseases
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DOI：
10.5799/ahinjs.01.2010.03.0200
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发表时间：
2010-12
影响因子：
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通讯作者：
M. Cojocaru;I. Cojocaru;I. Siloși;C. Vrabie
中科院分区：
文献类型：
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作者：
M. Cojocaru;I. Cojocaru;I. Siloși;C. Vrabie
动脉粥样硬化越来越被认为是免疫系统介导的血管系统过程。自身抗体、自身抗原、促炎细胞因子和感染因子在此过程中发挥作用。自身免疫相关的心血管疾病和动脉粥样硬化是重要的临床问题。自身免疫性风湿病患者动脉粥样硬化加速的原因尚不清楚。一些与自身免疫相关的心血管疾病病例可能与血栓形成比动脉粥样硬化更相关。尽管导致风险增加的机制尚未明确阐明，但传统和非传统风险因素（包括炎症）的结合似乎很重要。需要进一步的研究来确定这些自身免疫性风湿性疾病是否也与动脉粥样硬化加速及其表现相关。
Atherosclerosis is increasingly considered an immune system-mediated process of the vascular system. Autoantibodies, autoantigens, pro-inflammatory cytokines and infectious agents play a role in that process. Autoimmunity-related cardiovascular disease and atherosclerosis are important clinical problems. The reason for accelerated atherosclerosis in patients with autoimmune rheumatic diseases remains unclear. Some cases of autoimmunity-related cardiovascular disease may be more related to thrombosis than atherosclerosis. Although, mechanisms causing the increased risk are not precisely clarified, a combination of traditional and nontraditional risk factors, including inflammation appears to be of importance. Further studies are needed to determine whether these autoimmune rheumatic diseases are also associated with accelerated atherosclerosis and its manifestations.