Effects of phosphatidylserine on oxidative stress following intermittent running
Effects of phosphatidylserine on oxidative stress following intermittent running
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DOI：
10.1249/01.mss.0000175306.05465.7e
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发表时间：
2005-08-01
期刊：
影响因子：
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通讯作者：
Benton, D
中科院分区：
文献类型：
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作者：
Kingsley, MI;Wadsworth, D;Benton, D
目的：本研究的目的是研究750 mg大豆衍生磷脂酰丝氨酸或葡萄糖聚合物安慰剂，每天给药10天，对氧化应激标志物、感知疼痛和肌肉损伤的影响，这些标志物是由间歇性运动（旨在模拟足球比赛）引发的，随后立即进行力竭性跑步。研究方法：熟悉后，16名男子足球运动员完成了一个详尽的间歇性运动协议，在两个进一步的场合（T1和T2）分开约14天。在T2前10天，受试者以双盲方式被分配接受磷脂酰丝氨酸（PS）或安慰剂（P）。在两个主要的运动试验中，记录了运动至筋疲力尽的时间、短跑成绩、自感劳累的评分和心率。在休息时（运动前）、运动后15分钟（运动后）、运动后24小时（运动后24小时）和运动后48小时（运动后48小时）采集静脉血样。结果如下：运动前和运动后的血浆γ-生育酚浓度增加后补充PS，虽然补充没有影响其他非酶抗氧化剂（维生素C，α-生育酚，视黄醇和β-胡萝卜素）的血浆浓度。血清皮质醇浓度，感觉疼痛，肌肉损伤的标志物（肌酸激酶（CK）和肌红蛋白（Mb）），和脂质过氧化（氢过氧化物和共轭二烯滞后时间）升高到同等程度的PS和P力竭运动之前和之后的补充。在PS和P中从T1到T2的跑步至力竭时间的变化分别为4.2 +/-0.7和-3.7 +/-4.2%（P = 0.084）。结论：补充磷脂酰丝氨酸是没有有效的衰减皮质醇反应，感觉疼痛，肌肉损伤和脂质过氧化标记物后，力竭运行，但是，补充往往会增加运行时间耗尽。因此，未来的研究应进行调查的潜在ergogenic属性的补充。
Purpose: The aim of the study was to investigate the effects of 750 mg of soybean-derived phosphatidylserine or a glucose polymer placebo, administered daily for 10 d, on markers of oxidative stress, perceived soreness, and muscle damage initiated by intermittent exercise (designed to simulated soccer match play) immediately followed by an exhaustive run. Methods: Following familiarization, 16 male soccer players completed an exhaustive intermittent exercise protocol on two further occasions (T1 and T2) separated by approximately 14 d. Ten days before T2, the subjects were assigned, in a double-blind manner, to receive either phosphatidylserine (PS) or a placebo (P). Exercise time to exhaustion, sprint performance, ratings of perceived exertion, and HR were recorded throughout both main exercise trials. Venous blood samples were obtained at rest (preexercise), 15 min following exercise (postexercise), 24 h after exercise (post-24 h), and 48 It after exercise (post-48 h). Results: Preexercise and postexercise concentrations of plasma gamma-tocopherol were increased following supplementation in PS, although supplementation had no effect on plasma concentrations of other nonenzymatic antioxidants (vitamin C,, a-tocopherol, retinol, and beta-carotene). Serum cortisol concentrations, perceived soreness, markers of muscle damage (creatine kinase (CK) and myoglobin (Mb)), and lipid peroxidation (hydroperoxides and conjugated diene lag times) were elevated to an equal extent in PS and P following exhaustive exercise before and following supplementation. The changes in running times to exhaustion from T I to T2 in PS and P were 4.2 +/- 0.7 and -3.7 +/- 4.2%, respectively (P = 0.084). Conclusion: Supplementation with phosphatidylserine was not effective in attenuating the cortisol response, perceived soreness, and markers of muscle damage and lipid peroxidation following exhaustive running; however, supplementation tended to increase running time to exhaustion. Therefore, future research should be undertaken to investigate the potential ergogenic properties of this supplement.