Fluorescent ROMP Monomers and Copolymers for Biomedical Applications.
Fluorescent ROMP Monomers and Copolymers for Biomedical Applications.
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DOI：
10.1002/macp.201700273
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发表时间：
2017-11
影响因子：
2.5
通讯作者：
Esther K. Riga;David Boschert;M. Vöhringer;Vania Tanda Widyaya;Monika Kurowska;W. Hartleb;Karen Lienkamp
中科院分区：
文献类型：
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作者：
Esther K. Riga;David Boschert;M. Vöhringer;Vania Tanda Widyaya;Monika Kurowska;W. Hartleb;Karen Lienkamp
合成并表征了一系列分别以硝基苯并呋喃、香豆素和罗丹明B为荧光载体的绿色、蓝色和红色荧光的氧杂环丙稀酸和酰亚胺单体。凝胶渗透色谱和核磁共振谱表明，这些单体以氧杂冰片烯为聚合单元，通过开环歧化聚合(ROMP)很容易与生物活性官能团氧杂冰片烯发生共聚反应。由于这些单体的合成容易，而且与其他荧光探针相比，它们的成本效益更高，因此它们在生物材料应用中是有用的。
The synthesis and characterization of a series of green, blue and red-fluorescent exo-oxanorbornene acid and imide monomers carrying nitrobenzofurazan, coumarin, and Rhodamin B, respectively, as fluorophores is presented. These monomers carry oxanorbornene as polymerizable unit, and were readily copolymerized with bioactive functional oxanorbornene monomers by ring-opening metathesis polymerization (ROMP), as demonstrated by gel permeation chromatography and NMR spectroscopy. Due to the ease of synthesis of these monomers, and their cost-effectiveness compared many to other fluorescent probes, they are useful for biomaterials applications.