Ambient geothermal hydrogen sulfide exposure and peripheral neuropathy.
Ambient geothermal hydrogen sulfide exposure and peripheral neuropathy.
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DOI：
10.1016/j.neuro.2017.02.006
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发表时间：
2017-05
期刊：
影响因子：
3.4
通讯作者：
Bates MN
中科院分区：
文献类型：
--
作者：
Pope K;So YT;Crane J;Bates MN
硫化氢（H2S）气体的毒性机制被认为主要是通过对神经系统的影响而起作用。这种气体具有很高的急性毒性，但长期接触是否会引起周围神经病变等影响尚不清楚。新西兰的罗托鲁瓦市坐落在活跃的地热田上，人口中有一些最高的测量环境H2S暴露。先前在罗托鲁瓦进行的一项研究提供了H2S与周围神经病变相关的证据。使用临床方法，本研究试图调查并可能证实这种关联在罗托鲁瓦人口。研究人群包括1，635名罗托鲁瓦的成年居民，年龄在18-65岁之间。收集的与周围神经病变研究相关的数据包括症状、踝牵张反射、振动敏感性，如通过定时音叉测试和生物温度计（Bio-Medical Instrument Co.，俄亥俄州），以及通过单丝测量的轻触灵敏度。使用了一个暴露度量，估计了过去30年的时间加权H2S暴露。主成分分析用于联合收割机数据在可能的周围神经病变的各种指标。主要数据分析使用线性回归来检查周围神经功能指标与H2S暴露之间的关联。没有一个周围神经功能指标与H2S暴露相关，没有证据表明罗托鲁瓦发现的H2S暴露水平是周围神经病变的原因。硫化氢暴露和周围神经病诊断之间的早期关联可能归因于所使用的生态研究设计。不能完全排除H2S暴露分类错误导致缺乏相关性的可能性。
The mechanism of toxicity of hydrogen sulfide (H2S) gas is thought mainly to operate through effects on the nervous system. The gas has high acute toxicity, but whether chronic exposure causes effects, including peripheral neuropathy, is yet unclear. The city of Rotorua, New Zealand, sits on an active geothermal field and the population has some of the highest measured ambient H2S exposures. A previous study in Rotorua provided evidence that H2S is associated with peripheral neuropathy. Using clinical methods, the present study sought to investigate and possibly confirm this association in the Rotorua population. The study population comprised 1,635 adult residents of Rotorua, aged 18–65. Collected data relevant to the peripheral neuropathy investigation included symptoms, ankle stretch reflex, vibration sensitivity, as measured by the timed-tuning fork test and a Bio-Thesiometer (Bio-Medical Instrument Co., Ohio), and light touch sensitivity measured by monofilaments. An exposure metric, estimating time-weighted H2S exposure across the last 30 years was used. Principal components analysis was used to combine data across the various indicators of possible peripheral neuropathy. The main data analysis used linear regression to examine associations between the peripheral nerve function indicators and H2S exposure. None of the peripheral nerve function indicators were associated with H2S exposure, providing no evidence that H2S exposure at levels found in Rotorua is a cause of peripheral neuropathy. The earlier association between H2S exposure and peripheral neuropathy diagnoses may be attributable to the ecological study design used. The possibility that H2S exposure misclassification could account for the lack of association found cannot be entirely excluded.