Development of a thermosensitive hydrogel system for local delivery of 188Re colloid drugs
Development of a thermosensitive hydrogel system for local delivery of 188Re colloid drugs
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DOI：
10.1016/j.apradiso.2009.02.081
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发表时间：
2009-07-01
影响因子：
1.6
通讯作者：
Hsieh, Bor-Tsung
中科院分区：
文献类型：
--
作者：
Huang, Feng-Yun;Huang, Ling-Kuen;Hsieh, Bor-Tsung
利用壳聚糖基温敏水凝胶，建立了一种新型的Re-188-Tin胶体局部控释内照射治疗模式。以壳聚糖（C）和β-甘油磷酸盐（β-GP）为原料，制备温度敏感性水凝胶（C/GP）。所制备的C/GP水凝胶在37 ℃的环境中5 min内具有快速的溶胶-凝胶转变。制备的Re-188-锡胶体的标记效率为93.9 ± 0.6%，离心后可提高到98%以上。Re-188-锡胶体的平均粒径为12.1 +/- 1.2 μ m，只有7.2 +/- 1.5%小于1 μ m。闪烁照相研究显示，C/GP水凝胶中所含的Re-188-锡胶体在注射后长达48小时内位于注射部位周围（>91%），验证了IRT设计的预期功能。本研究开发的新形式的IRT可能是一种有效的治疗模式，区域放射治疗。(C)2009爱思唯尔有限公司保留所有权利。
A novel internal radiation therapy (IRT) mode intended for controlled local delivery of Re-188-Tin colloid was developed by using chitosan-based thermosensitive hydrogel. Chitosan (C) and beta-glycerophosphate (beta-GP) were used to prepare the thermosensitive hydrogel (C/GP). The prepared C/GP hydrogel featured a rapid sol-gel transition within 5 min after it was brought into an environment of 37 degrees C. Re-188-Tin colloid was prepared with labeling efficiency of 93.9 +/- 0.6%, and could be increased to more than 98% following centrifugation. The average particle size of Re-188-Tin colloid was 12.1 +/- 1.2 mu m, with only 7.2 +/- 1.5% less than 1 mu m. Scintigraphic study showed that Re-188-Tin colloid contained in the C/GP hydrogel was localized (>91%) around the injection site for up to 48 h post injection, verifying the intended function of the IRT design. The developed novel form of IRT in this study could be an effective treatment mode for regional radiotherapy. (C) 2009 Elsevier Ltd. All rights reserved.