Sir Isaac Newton, sepsis, SIRS, and CARS
Sir Isaac Newton, sepsis, SIRS, and CARS
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DOI：
10.1097/00003246-199607000-00010
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发表时间：
1996-07-01
影响因子：
8.8
通讯作者：
Bone, RC
中科院分区：
文献类型：
--
作者：
Bone, RC
这句格言由艾萨克·牛顿爵士 [1] 于 1687 年在他的《自然哲学数学原理》中提出，是科学的基本原理之一。生物系统，例如人体，比艾萨克爵士所描述的简单物理系统更为复杂。尽管如此，这句格言帮助我们理解为什么脓毒症新疗法的试验失败了。 在人体中，我们对感染或损伤的反应还有很多不了解的地方，还有许多生物学现象仍然未知。然而，很明显，身体可能会对受伤或感染产生过度反应、反应不足或平衡反应。
This maxim, formulated in 1687 by Sir Isaac Newton [1] in his Philosophiae Naturalis Principia Mathematica, is one of the fundamental principles of science. Biological systems, such as the human body, are more complicated than the simple physical systems Sir Isaac was describing. Nevertheless, this maxim helps us understand why the trials of new therapies for sepsis have failed.In the human body, there is much we still do not understand about the response to infection or injury, and there are many biological phenomena that remain unknown. However, it is clear that the body can mount an overreaction, an underreaction, or a balanced reaction to injury or infection.