CONSTITUTIVE MODELING OF ARTICULAR-CARTILAGE AND BIOMACROMOLECULAR SOLUTIONS
CONSTITUTIVE MODELING OF ARTICULAR-CARTILAGE AND BIOMACROMOLECULAR SOLUTIONS
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DOI：
10.1115/1.2895527
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发表时间：
1993-11-01
影响因子：
1.7
通讯作者：
ZHU, WB
中科院分区：
文献类型：
--
作者：
LAI, WM;MOW, VC;ZHU, WB
关节软骨是关节内长骨末端的承重材料。这些关节必须承受在缓慢循环条件下施加的非常高的载荷（体重的数倍）。在正常的生理状态下，关节软骨必须承受这些严重的负荷条件超过七十年，没有过度的磨损和撕裂。因此，在关节中，关节软骨必须在摩擦、润滑和磨损方面有效地发挥作用[1]。软骨的机械性破坏，通常从第三个十年开始，导致骨关节病。正因为如此，过去二十年的研究越来越多地集中在确定关节软骨的生物力学和物理化学特性上，特别关注它们如何与其生化组成以及分子和超微结构组织相关[1]。
Articular cartilage is the bearing material which lines the ends of long bones within diarthrodial joints. These joints must bear very high loads (several times body weight) applied under slow cyclical conditions. Within normal physiologic states, articular cartilage must endure these severe loading conditions for more than seven decades, without excessive wear and tear. Thus, in the joint, articular cartilage must function efficiently in terms of friction, lubrication and wear [1]. Mechanical breakdown of cartilage, often from the third decade on, leads to osteoarthrosis. Because of this, research over the past two decades have increasingly focused on determining the biomechanical and physicochemical properties of articular cartilage, with particular focus on how they might be related to its biochemical composition, and molecular and ultrastructural organization [1],