Hyperthermically induced changes in high spectral and spatial resolution MR images of tumor tissue--a pilot study.
Hyperthermically induced changes in high spectral and spatial resolution MR images of tumor tissue--a pilot study.
复制标题
DOI：
10.1088/0031-9155/57/9/2653
复制
发表时间：
2012-05-07
影响因子：
3.5
通讯作者：
Karczmar GS
中科院分区：
文献类型：
--
作者：
Foxley S;Fan X;River J;Zamora M;Markiewicz E;Sokka S;Karczmar GS
This pilot study investigated the feasibility of using MRI based on BOLD (blood oxygen level dependent) contrast to detect physiological effects of locally induced hyperthermia in a rodent tumor model. Nude mice bearing AT6.1 rodent prostate tumors inoculated in the hind leg were imaged at 9.4T scanner using a multi-gradient echo pulse sequence to acquire high spectral and spatial resolution (HiSS) data. Approximately 6 °C increases were produced locally in tumor tissue using fiber optic guided light from a 250 W halogen lamp. HiSS data were acquired over three slices through the tumor and leg both prior to and during heating. Water spectra were produced from these datasets for each voxel at each time point. Time dependent changes in water resonance peak width were measured during 15 minutes of localized tumor heating. The results demonstrated that hyperthermia produced both significant increases and decreases in water resonance peak width. Average decreases in peak width were significantly larger in the tumor rim than in normal muscle (p = 0.04). The effect of hyperthermia in tumor was spatially heterogeneous, i.e., the standard deviation of the change in peak width was significantly larger in the tumor rim than in normal muscle (p = 0.005). Therefore, mild hyperthermia produces spatially heterogeneous changes in water peak width in both tumor and muscle. This may reflect heterogeneous effects of hyperthermia on local oxygenation. The peak width changes in tumor and muscle were significantly different, perhaps due to abnormal tumor vasculature and metabolism. Response to hyperthermia measured by MRI may be useful for identifying and/or characterizing suspicious lesions as well as guiding development of new hyperthermia protocols.
登录
查看更多内容
影响因子：
3.3
作者：
CHU, SCK;XU, Y;SPRINGER, CS
通讯作者：
SPRINGER, CS
影响因子：
3.3
作者：
GRUETTER, R
通讯作者：
GRUETTER, R
影响因子：
3.4
作者：
Chang, CC;Sun, W;Trosko, JE
通讯作者：
Trosko, JE
影响因子：
4.6
作者：
SONG, CW;LOKSHINA, A;LEVITT, SH
通讯作者：
LEVITT, SH
影响因子：
4.4
作者：
HINDMAN, JC
通讯作者：
HINDMAN, JC