Anti-inflammatory Properties of Cerium Oxide Nanoparticles
Anti-inflammatory Properties of Cerium Oxide Nanoparticles
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DOI：
10.1002/smll.200901048
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发表时间：
2009-12-04
期刊：
影响因子：
13.3
通讯作者：
Reilly, Christopher M.
中科院分区：
文献类型：
--
作者：
Hirst, Suzanne M.;Karakoti, Ajay S.;Reilly, Christopher M.
氧化铈纳米颗粒的价态和氧缺陷性质表明，它们可能是自再生的自由基清除剂。由酶诱导的一氧化氮合酶(INOS)过量产生的自由基一氧化氮(NO)被认为是炎症的关键介质。NO与疾病活动性相关，并促进组织破坏。研究了纳米氧化钙对J774A.1小鼠巨噬细胞清除自由基或活性氧(ROS)和抑制炎症介质产生的能力。细胞内化纳米陶瓷，治疗是无毒的，氧化应激和促炎iNOS蛋白的表达随着刺激而减弱。体内研究表明，纳米钙沉积在小鼠组织中，没有致病性。综上所述，这表明氧化铈纳米颗粒在小鼠体内的耐受性很好，并被整合到细胞组织中。此外，纳米氧化钙可能有可能减少炎症状态下ROS的产生，从而成为治疗慢性炎症的一种新疗法。
The valence and oxygen defect properties of cerium oxide nanoparticles (nanoceria) suggest that they may act as auto-regenerative free radical scavengers. Overproduction of the free radical nitric oxide (NO) by the enzyme inducible nitric oxide synthase (iNOS) has been implicated as a critical mediator of inflammation. NO is correlated with disease activity and contributes to tissue destruction. The ability of nanoceria to scavenge free radicals, or reactive oxygen species (ROS), and inhibit inflammatory mediator production in J774A.1 murine macrophages is investigated. Cells internalize nanoceria, the treatment is nontoxic, and oxidative stress and pro-inflammatory iNOS protein expression are abated with stimulation. In vivo studies show nanoceria deposition in mouse tissues with no pathogenicity. Taken together, it is suggested that cerium oxide nanoparticles are well tolerated in mice and are incorporated into cellular tissues. Furthermore, nanoceria may have the potential to reduce ROS production in states of inflammation and therefore serve as a novel therapy for chronic inflammation.